Evidence map›Paper›PMID 36427109›Full record

ReviewCellular and molecular neurobiology2023

The Role of Retinal Dysfunction in Myopia Development.

Yuke Huang, Xi Chen, Jing Zhuang, Keming Yu

Open access · greenAbstract readReview
In one paragraph

Review in Cellular and molecular neurobiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 22 citations in OpenAlex.

  1. Acute Ocular Effects of Violet and Red Light Exposure in Young Adults.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. S-Cone Retinal Pathway Dysfunction in Myopia.Investigative ophthalmology & visual science · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yuke Huang *State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guang-Dong Provincial Key Laboratory of Ophthalmology and Visual Science, Sun Yat-Sen University, No.7 Jinsui Road, Tianhe District, Guangzhou City, China.
Xi Chen *State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guang-Dong Provincial Key Laboratory of Ophthalmology and Visual Science, Sun Yat-Sen University, No.7 Jinsui Road, Tianhe District, Guangzhou City, China.
Jing ZhuangState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guang-Dong Provincial Key Laboratory of Ophthalmology and Visual Science, Sun Yat-Sen University, No.7 Jinsui Road, Tianhe District, Guangzhou City, China.
Keming YuState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guang-Dong Provincial Key Laboratory of Ophthalmology and Visual Science, Sun Yat-Sen University, No.7 Jinsui Road, Tianhe District, Guangzhou City, China. yukeming@mail.sysu.edu.cn.
Sun Yat-sen University · CN

Funding

National Natural Science Foundation of China 81900850
6 · The paper itself

Abstract

Myopia is a refractive disorder arising from a mismatch between refractive power and relatively long axial length of the eye. With its dramatically increasing prevalence, myopia has become a pervasive social problem. It is commonly accepted that abnormal visual input acts as an initiating factor of myopia. As the first station to perceive visual signals, the retina plays an important role in myopia etiology. The retina is a fine-layered structure with multitudinous cells, processing intricate visual signals via numerous molecular pathways. Accordingly, dopaminergic mechanisms, contributions of rod and cone photoreceptors, myopic structural changes of retinal pigment epithelium (RPE) and neuro-retinal layers have all suggested a vital role of retinal dysfunction in myopia development. Herein, we separately discuss myopia-related retinal dysfunction and current dilemmas by different levels, from molecules to cells, with the hope that the comprehensive delineation could contribute to a better understanding of myopia etiology, indicate novel therapeutic targets, and inspire future studies.

Indexed as

MyopiaRetinaHumansRetinal Pigment EpitheliummiRNAsMyopiaNeuronsNeurotransmittersRetinaRetinal structure

Identifiers

PMID36427109
PMCPMC11412200
OpenAlexW4310078138

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.