ReviewPhysiological research2022
Healthy microbiome - a mere idea or a sound concept?
Review in Physiological research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Stress and the Immune System: Insights From Psychoneuroimmunology.Physiological research · 2026Review
- The gut microbiome and ageing trajectories: mechanisms and clinical implications.Nature reviews. Endocrinology · 2026Review
- Gut Microbiota Diversity and Composition Across Shift Types and the Effects of Walnut Supplementation-An Observational and Interventional Study.International journal of environmental research and public health · 2026Observational
- Gut Healthism: The Penetrating Gaze and Depoliticising Forces of Direct-to-Consumer Microbiome Testing Kits.Sociology of health & illness · 2025Article
- Examining the healthy human microbiome concept.Nature reviews. Microbiology · 2025Review
- Experimental tests challenge the evidence of a healthy human blood microbiome.The FEBS journal · 2025Article
- Should the Faecal Microbiota Composition Be Determined to Certify a Faecal Donor?Diagnostics (Basel, Switzerland) · 2024Article
- Effects of glucose and lactate onMicrobiology spectrum · 2024Article
- Diabetes and gut microbiome.Frontiers in microbiology · 2024Review
- A Taxonomy-Agnostic Approach to Targeted Microbiome Therapeutics-Leveraging Principles of Systems Biology.Pathogens (Basel, Switzerland) · 2023Review
- Protective Effect of Vegan Microbiota on Liver Steatosis Is Conveyed by Dietary Fiber: Implications for Fecal Microbiota Transfer Therapy.Nutrients · 2023Article
- Cutaneous Dysbiosis and Dermatophytosis: The Unexplored Link.Indian journal of dermatologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hundreds of studies in last decades have aimed to compare the microbiome of patients suffering from diverse diseases with that of healthy controls. The microbiome-related component was additionally identified in pathophysiology of many diseases formerly considered to depend only on the host physiology. This, however, opens important questions like: "What is the healthy microbiome?" or "Is it possible to define it unequivocally?". In this review, we describe the main hindrances complicating the definition of "healthy microbiome" in terms of microbiota composition. We discuss the human microbiome from the perspective of classical ecology and we advocate for the shift from the stress on microbiota composition to the functions that microbiome ensures for the host. Finally, we propose to leave the concept of ideal healthy microbiome and replace it by focus on microbiome advantageous for the host, which always depends on the specific context like the age, genetics, dietary habits, body site or physiological state.
Indexed as
Identifiers
36426891PMC9814986What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.