Evidence map›Paper›PMID 36426712›Full record

ArticleExperimental biology and medicine (Maywood, N.J.)2023

CX3CR1 deficiency exacerbates immune-mediated hepatitis by increasing NF-κB-mediated cytokine production in macrophage and T cell.

Mi Ren, Jinyan Zhang, Shen Dai, Chenxiao Wang, Zheng Chen, Siqi Zhang, Junming Xu, Xuebin Qin, Fengming Liu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental biology and medicine (Maywood, N.J.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Liver Macrophages in the Pathogenesis of Viral Hepatitis.Current issues in molecular biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Mi RenDepartment of Hepatobiliary Surgery and Liver Transplantation, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, People's Republic of China.
Jinyan ZhangDepartment of Hepatobiliary Surgery and Liver Transplantation, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, People's Republic of China.
Shen DaiDivision of Comparative Pathology, Tulane National Primate Research Center, Covington, LA 70433, USA.
Chenxiao WangDivision of Comparative Pathology, Tulane National Primate Research Center, Covington, LA 70433, USA.
Zheng ChenDivision of Comparative Pathology, Tulane National Primate Research Center, Covington, LA 70433, USA.
Siqi ZhangDepartment of Hepatobiliary Surgery and Liver Transplantation, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, People's Republic of China.
Junming XuDepartment of Hepatobiliary Surgery and Liver Transplantation, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, People's Republic of China.
Xuebin QinDivision of Comparative Pathology, Tulane National Primate Research Center, Covington, LA 70433, USA.
Fengming LiuDepartment of Immunology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250000, People's Republic of China.ORCID 0000-0002-8815-3356
Tulane University · USShanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune-mediated hepatitis is marked by liver inflammation characterized by immune cell infiltration, chemokine/cytokine production, and hepatocyte injury. C-X3C motif receptor 1 (CX3CR1), as the receptor of chemokine C-X3C motif ligand 1 (CX3CL1)/fractalkine, is mainly expressed on immune cells including monocytes and T cells. Previous studies have shown that CX3CR1 protects against liver fibrosis, but the exact role of CX3CL1/CX3CR1 in acute immune-mediated hepatitis remains unknown. Here, we investigate the role of the CX3CL1/CX3CR1 axis in immune-mediated hepatitis using concanavalin A (ConA)-induced liver injury model in CX3CR1-deficient

Indexed as

Chemical and Drug Induced Liver Injury, ChronicHepatitisAnimalsCX3C Chemokine Receptor 1CytokinesInterferon-gammaMacrophagesMiceMice, Inbred C57BLNF-kappa BT-LymphocytesTumor Necrosis Factor-alphaCX3C Chemokine Receptor 1Cx3cr1 protein, mouseCytokinesInterferon-gammaNF-kappa BTumor Necrosis Factor-alphaCX3CR1immune-mediated hepatitismacrophageNF-κB p65T cell

Identifiers

PMID36426712
PMCPMC10041049
OpenAlexW4310046162

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.