Evidence map›Paper›PMID 36426684›Full record

ArticleAnatomical record (Hoboken, N.J. : 2007)2025

Absence of IκBβ/NFκB signaling does not attenuate acetaminophen-induced hepatic injury.

Mack Solar, Maya R Grayck, William C McCarthy, Lijun Zheng, Oscar A Lacayo, Laura G Sherlock, Ruby Zhou, David J Orlicky, Clyde J Wright

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Anatomical record (Hoboken, N.J. : 2007), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Mack SolarSection of Neonatology, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA.
Maya R GrayckSection of Neonatology, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA.
William C McCarthySection of Neonatology, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA.
Lijun ZhengSection of Neonatology, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA.
Oscar A LacayoSection of Neonatology, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA.
Laura G SherlockSection of Neonatology, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA.
Ruby ZhouSection of Neonatology, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA.
David J OrlickyDepartment of Pathology, University of Colorado Anschutz School of Medicine, Aurora, Colorado, USA.
Clyde J WrightSection of Neonatology, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA.ORCID 0000-0002-8449-5631
University of Colorado Denver · USUniversity of Colorado Anschutz Medical Campus · US

Funding

Role of hepatic IkBb-mediated sustained NFkB activation in neonatal lung injury and abnormal developmentR01HL132941 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI WRIGHT, CLYDE JASON · 2017 to 2021
$2.3M
Research Supplement to Promote Diversity in Health Related Research: Pulmonary implications ofperinatal acetaminophen exposureR01HD107700 · NICHD · UNIVERSITY OF COLORADO DENVER · PI Clyde Jason Wright · 2022 to 2026
$2.2M
Eunice Kennedy Shriver National Institute of Child Health and Human Development R01HD107700K12 Child Health ResearchNHLBI NIH HHS R01 HL132941NHLBI NIH HHS R01HL132941NICHD NIH HHS R01 HD107700
6 · The paper itself

Abstract

Acetaminophen (N-acetyl-p-aminophenol [APAP]) toxicity is a common cause of acute liver failure. Innate immune signaling and specifically NFκB activation play a complex role in mediating the hepatic response to toxic APAP exposures. While inflammatory innate immune responses contribute to APAP-induced injury, these same pathways play a role in regeneration and repair. Previous studies have shown that attenuating IκBβ/NFκB signaling downstream of TLR4 activation can limit injury, but whether this pathway contributes to APAP-induced hepatic injury is unknown. We hypothesized that the absence of IκBβ/NFκB signaling in the setting of toxic APAP exposure would attenuate APAP-induced hepatic injury. To test this, we exposed adult male WT and IκBβ

Indexed as

AcetaminophenChemical and Drug Induced Liver InjuryI-kappa B ProteinsLiverNF-kappa BSignal TransductionAnimalsMaleMiceMice, Inbred C57BLMice, KnockoutAcetaminophenI kappa B beta proteinI-kappa B ProteinsNF-kappa BacetaminophenhistopathologyIκBβliver injuryNFκB

Identifiers

PMID36426684
PMCPMC10209348
OpenAlexW4309938186

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.