Evidence map›Paper›PMID 36426541›Full record

ReviewNeurorehabilitation and neural repair2022

Brain-Computer Interface-Controlled Exoskeletons in Clinical Neurorehabilitation: Ready or Not?

Annalisa Colucci, Mareike Vermehren, Alessia Cavallo, Cornelius Angerhöfer, Niels Peekhaus, Loredana Zollo, Won-Seok Kim, Nam-Jong Paik, Surjo R Soekadar

Registry-linked trialOpen access · hybridAbstract readReview
In one paragraph

Review in Neurorehabilitation and neural repair, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07553416 (A Prospective, Randomized, Parallel-Controlled Clinical Study Protocol of Non-Invasive Brain Computer Interface Robot Based on Mirror Rehabilitation Theory in the Treatment of Upper Limb Motor Function Disorder After Stroke), which is not on this map. Cited by 33 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 3 pooled it
8.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07553416 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Prospective, Randomized, Parallel-Controlled Clinical Study Protocol of Non-Invasive Brain Computer Interface Robot Based on Mirror Rehabilitation Theory in the Treatment of Upper Limb Motor Function Disorder After Stroke

TypeinterventionalSponsorBeijing Tiantan HospitalRan2026 to 2027Enrolled40ConditionsIschemic Stroke, Intracranial Haemorrhage, Brain-Computer Interfaces, Rehabilitation ExerciseArmsBrain computer interface-robotic mirror therapy
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 83 citations in OpenAlex.

  1. Pooled it
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  13. Brain-computer interface: an update for the clinicians.Frontiers in human neuroscience · 2026
    Review
  14. Article
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  16. TMS-Based Neurofeedback Training of Mental Finger Individuation Induces Neuroplastic Changes in the Sensorimotor System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  17. Brain-Computer Interfaces for Stroke Motor Rehabilitation.Bioengineering (Basel, Switzerland) · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Annalisa ColucciClinical Neurotechnology Laboratory, Neurowissenschaftliches Forschungszentrum (NWFZ), Department of Psychiatry and Neurosciences, Charité Campus Mitte (CCM), Charité - Universitätsmedizin Berlin, Charitéplatz 1, Berlin, Germany.
Mareike VermehrenClinical Neurotechnology Laboratory, Neurowissenschaftliches Forschungszentrum (NWFZ), Department of Psychiatry and Neurosciences, Charité Campus Mitte (CCM), Charité - Universitätsmedizin Berlin, Charitéplatz 1, Berlin, Germany.
Alessia CavalloClinical Neurotechnology Laboratory, Neurowissenschaftliches Forschungszentrum (NWFZ), Department of Psychiatry and Neurosciences, Charité Campus Mitte (CCM), Charité - Universitätsmedizin Berlin, Charitéplatz 1, Berlin, Germany.
Cornelius AngerhöferClinical Neurotechnology Laboratory, Neurowissenschaftliches Forschungszentrum (NWFZ), Department of Psychiatry and Neurosciences, Charité Campus Mitte (CCM), Charité - Universitätsmedizin Berlin, Charitéplatz 1, Berlin, Germany.
Niels PeekhausClinical Neurotechnology Laboratory, Neurowissenschaftliches Forschungszentrum (NWFZ), Department of Psychiatry and Neurosciences, Charité Campus Mitte (CCM), Charité - Universitätsmedizin Berlin, Charitéplatz 1, Berlin, Germany.
Loredana ZolloUnit of Advanced Robotics and Human-Centred Technologies (CREO Lab), University Campus Bio-Medico of Rome, Roma RM, Italy.
Won-Seok KimDepartment of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Bundang-gu, Seongnam-si, Gyeonggi-do, Republic of Korea.ORCID 0000-0002-1199-5707
Nam-Jong PaikDepartment of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Bundang-gu, Seongnam-si, Gyeonggi-do, Republic of Korea.ORCID 0000-0002-5193-8678
Surjo R SoekadarClinical Neurotechnology Laboratory, Neurowissenschaftliches Forschungszentrum (NWFZ), Department of Psychiatry and Neurosciences, Charité Campus Mitte (CCM), Charité - Universitätsmedizin Berlin, Charitéplatz 1, Berlin, Germany.ORCID 0000-0003-1280-5538
Charité - Universitätsmedizin Berlin · DESeoul National University Bundang Hospital · KRUniversità Campus Bio-Medico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of brain-computer interface-controlled exoskeletons promises new treatment strategies for neurorehabilitation after stroke or spinal cord injury. By converting brain/neural activity into control signals of wearable actuators, brain/neural exoskeletons (B/NEs) enable the execution of movements despite impaired motor function. Beyond the use as assistive devices, it was shown that-upon repeated use over several weeks-B/NEs can trigger motor recovery, even in chronic paralysis. Recent development of lightweight robotic actuators, comfortable and portable real-world brain recordings, as well as reliable brain/neural control strategies have paved the way for B/NEs to enter clinical care. Although B/NEs are now technically ready for broader clinical use, their promotion will critically depend on early adopters, for example, research-oriented physiotherapists or clinicians who are open for innovation. Data collected by early adopters will further elucidate the underlying mechanisms of B/NE-triggered motor recovery and play a key role in increasing efficacy of personalized treatment strategies. Moreover, early adopters will provide indispensable feedback to the manufacturers necessary to further improve robustness, applicability, and adoption of B/NEs into existing therapy plans.

Indexed as

Brain-Computer InterfacesExoskeleton DeviceNeurological RehabilitationRoboticsBrainHumansbrain–computer interface (BCI)clinical translationexoskeletonsmotor recoverystroke

Identifiers

PMID36426541
PMCPMC9720703
OpenAlexW4309971721

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.