Evidence map›Paper›PMID 36426397›Full record

ArticleAllergy, asthma & immunology research2022

Phenotype of Atopic Dermatitis With Food Allergy Predicts Development of Childhood Asthma via Gut Wnt Signaling.

So-Yeon Lee, Sangrok Kim, Mi Jin Kang, Kun-Baek Song, Eom Ji Choi, Sungsu Jung, Ji-Sun Yoon, Dong In Suh, Youn Ho Shin, Kyung Won Kim and 2 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Allergy, asthma & immunology research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Machine learning-derived asthma and allergy trajectories in children: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2025
    Pooled it
  2. Article
  3. Review
  4. Review
  5. Effect of Topical Corticosteroid Treatment on microRNA Expression in Infants with Atopic Dermatitis.JID innovations : skin science from molecules to population health · 2025
    Article
  6. Genetic/Protein Association of Atopic Dermatitis and Tooth Agenesis.International journal of molecular sciences · 2023
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

So-Yeon LeeDepartment of Pediatrics, Childhood Asthma and Atopy Center, Humidifier Disinfectant Health Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Sangrok KimDepartment of Information Management, Medical Record Information Team, Hanyang University Medical Center, Seoul, Korea.
Mi Jin KangHumidifier Disinfectant Health Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Kun-Baek SongDepartment of Pediatrics, Soonchunhyang Cheonan Hospital, University of Soonchunhyang College of Medicine, Cheonan, Korea.
Eom Ji ChoiDepartment of Pediatrics, Childhood Asthma and Atopy Center, Humidifier Disinfectant Health Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Sungsu JungDepartment of Pediatrics, Pusan National University Yangsan Hospital, Yangsan, Korea.
Ji-Sun YoonDepartment of Pediatrics, Chung-Ang University Hospital, Gwangmyeong, Korea.
Dong In SuhDepartment of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.
Youn Ho ShinDepartment of Pediatrics, CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Korea.
Kyung Won KimDepartment of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.
Kangmo AhnDepartment of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Soo-Jong HongDepartment of Pediatrics, Childhood Asthma and Atopy Center, Humidifier Disinfectant Health Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. sjhong@amc.seoul.kr.
CHA University · KRPusan National University Yangsan Hospital · KRSeoul National University · KRSungkyunkwan University · KRUlsan College · KRYonsei University · KR

Funding

Korea Disease Control and Prevention Agency 2008-E33030-00Korea Disease Control and Prevention Agency 2009-E33033-00Korea Disease Control and Prevention Agency 2011-E33021-00Korea Disease Control and Prevention Agency 2012-E33012-00Korea Disease Control and Prevention Agency 2013-E51003-00Korea Disease Control and Prevention Agency 2014-E51004-00Korea Disease Control and Prevention Agency 2014-E5 1004-01Korea Disease Control and Prevention Agency 2014-E5 1004-02Korea Disease Control and Prevention Agency 2017-E6 7002-00Korea Disease Control and Prevention Agency 2017-E6 7002-01Korea Disease Control and Prevention Agency 2017-E6 7002-02National Research Foundation of Korea NRF-2020R1A2C2012822
6 · The paper itself

Abstract

purposeAtopic dermatitis (AD) is a chronic inflammatory skin disease characterized by a wide spectrum of clinical phenotype. However, specific description of phenotypes of AD depending on the comorbidities in early childhood is lacking. This study aimed to investigate whether the AD phenotype in early childhood is related to childhood asthma and to elucidate the mechanisms involved.

methodsData on the first 3 years of life were collected prospectively from 1,699 children in the COhort for Childhood Origin of Asthma and allergic diseases (COCOA). We applied an unsupervised latent class analysis to the following five factors: food sensitization, inhalant sensitization, food allergy (FA), AD, and recurrent wheezing. The risks of developing FA, AD, allergic rhinitis (AR), and asthma in children aged 5-7 years were evaluated. Colonocyte transcriptome and ingenuity pathway analysis were performed.

resultsFour phenotypes were identified; no allergic diseases (78.4%), AD without sensitization (16.4%), FA with AD (2.9%), and AD with sensitization (7.8%). The FA with AD had the highest risk for FA, AR, and asthma and the highest cord blood immunoglobulin E (IgE) levels. In AD without sensitization and with sensitization, scoring of AD (SCORAD) in early childhood was higher than in FA with AD. Canonical pathway analysis with the colonocyte transcriptome revealed that the key pathway in FA with AD was 'Wnt/β-catenin Signaling.' The relative abundance of

conclusionsWhen FA is present in various phenotypes of AD at early life, regardless of severity of eczema, it may be associated with gut Wnt signaling and later development of asthma.

Indexed as

Asthmaatopicdermatitisfood hypersensitivitylatent class analysisphenotypetranscriptomeWnt signaling pathway

Identifiers

PMID36426397
PMCPMC9709687
OpenAlexW4310331591

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.