ReviewAllergy, asthma & immunology research2022
Chinese Guideline on Allergen Immunotherapy for Allergic Rhinitis: The 2022 Update.
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Review in Allergy, asthma & immunology research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34citing papers in PubMed
7.7field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 64 citations in OpenAlex.
- A multicenter randomized study: safety of an optimized accelerated house dust mite immunotherapy for patients with allergic rhinitis in China (PERFECT study).Frontiers in immunology · 2026Trial
- Nasal saline irrigation with azelastine-fluticasone nasal spray in moderate-to-severe persistent allergic rhinitis: a randomized controlled trial.Frontiers in allergy · 2025Trial
- Recent advances in allergen immunotherapy.Chinese medical journal · 2026Review
- Unraveling the increasing burden of allergies: Spatiotemporal dynamics of pollen allergy risk in China.Eco-Environment & Health · 2026Article
- Forecasting seasonal allergic rhinitis through integrated analysis of social media and online drug sales data.The World Allergy Organization journal · 2026Article
- Study ofInternational journal of molecular sciences · 2026Article
- Article
- Knowledge, attitudes, and practice towards allergen-specific immunotherapy in parents with children having allergic rhinitis: a cross-sectional study in Wuxi.BMC pediatrics · 2026Article
- Multi-targeted protection of Yuping Tongqiao against allergic rhinitis: suppression of inflammatory response via TSLP signaling and reinforcement of epithelial barrier integrity via AhR signaling.Frontiers in allergy · 2026Article
- Comorbidity of Allergic Asthma and Rhinitis and High Allergen-Specific IgE are Risk Factors for Systemic Reactions to House Dust Mite Immunotherapy in Children.Journal of asthma and allergy · 2026Article
- Local immune and inflammatory endotypes of the nasal mucosa in allergic and non-allergic chronic rhinitis.Frontiers in immunology · 2026Article
- Serum metabolomic profiling identifies taurolithocholic acid as a predictor of HDM-SCIT response in allergic rhinitis: clinical discovery and experimental validation.Frontiers in immunology · 2026Article
- RGS1 induces nasal epithelial barrier dysfunction in allergic rhinitis by modulating NF-κB/AQP5 axis.Cytotechnology · 2025Article
- Landscape of Aeroallergen Sensitization in Asia.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2025Review
- Allergic rhinitis in college students at Dongguan: a cross-sectional survey on disease burden, knowledge, and self-management.Frontiers in allergy · 2025Article
- A study of specific immunoglobulin G4 expression in allergic rhinitis and its value in assessing efficacy and in predicting prognosis of sublingual immunotherapy.The Kaohsiung journal of medical sciences · 2025Article
- Predicting the effectiveness of omalizumab in patients with refractory chronic rhinosinusitis with nasal polyps comorbid with asthma based on inflammatory biomarkers.The World Allergy Organization journal · 2025Article
- Analysis of gender- and age-stratified asthma burden: forecasting prevalence trends in 2030.Frontiers in medicine · 2025Article
- Reliability and validity of a newly developed self-administrated online questionnaire assessing the quality of life for allergic rhinitis in China: The QoLAR.Journal of education and health promotion · 2025Article
- Elevated SerpinB2 regulates MUC5AC expression via STAT6 signaling in nasal epithelial cells in allergic rhinitis.Frontiers in immunology · 2025Article
Corrections and comments
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Authors and funding
62 authors at 20 institutions in 2 countries.
Chengshuo Wang *Department of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0003-0646-5135
Yixiao Bao *Shanghai Tonxin Clinic, Shanghai, China.
Jianjun Chen *Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.ORCID https://orcid.org/0000-0002-8631-4558
Xiaoyang Chen *Department of Pulmonary and Critical Care Medicine, Second Affiliated Hospitial of Fujian Medical University, Respiratory Medicine Center of Fujian Province, Quanzhou, China.ORCID https://orcid.org/0000-0002-2533-1928
Lei Cheng *Department of Otorhinolaryngology & Clinical Allergy Center, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.ORCID https://orcid.org/0000-0001-6541-7702
Yin Shi Guo *Department of Allergy & Immunology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.ORCID https://orcid.org/0000-0002-2629-8875
Chuangli Hao *Department of Respiratory Diseases, Children's Hospital of Soochow University, Suzhou, China.ORCID https://orcid.org/0000-0002-8203-0603
He Lai *Department of Allergy, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0000-0001-6914-9813
Huabin Li *Department of Otolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-2477-2879
Jing Li *Department of Allergy and Clinical Immunology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0000-0002-6459-7470
Changshan Liu *Department of Pediatrics, The Second Hospital of Tianjin Medical University, Tianjin, China.ORCID https://orcid.org/0000-0002-1828-8204
Yun Liu *Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Zheng Liu *Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.ORCID https://orcid.org/0000-0002-4168-6702
Hongfei Lou *Department of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0002-8553-812X
Wei Lv *Department of Otorhinolaryngology, Peking Union Medical College Hospital, Beijing, China.ORCID https://orcid.org/0000-0003-0127-8824
Guangmin Nong *Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Qianhui Qiu *Department of Otolaryngology-Head and Neck Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.ORCID https://orcid.org/0000-0001-6335-5173
Xiumin Ren *Department of Otorhinolaryngology Head and Neck Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Jie Shao *Department of Pediatrics, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yi-Hong Shen *Department of Respiratory Diseases, The First Affiliated Hospital of College of Medicine, Zhejiang University, Hangzhou, China.ORCID https://orcid.org/0000-0002-7815-9973
Li Shi *Department of Otolaryngology,The Second Hospital of Shandong University, Jinan, China.ORCID https://orcid.org/0000-0002-4162-7876
Xi-Cheng Song *Department of Otorhinolaryngology Head and Neck Surgery, Yuhuangding Hospital of Qingdao University, Yantai, China.ORCID https://orcid.org/0000-0002-9789-1318
Yuxin Song *Department of Allergy, Harbin Children's Hospital, Harbin, China.
Suping Tang *Department of Allergy, Fuzhou Children's Hospital Affiliated to Fujian Medical University, Fuzhou, China.ORCID https://orcid.org/0000-0001-9175-7145
Hongtian Wang *Department of Allergy, Beijing ShiJiTan Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0001-7204-7527
Xiangdong Wang *Department of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0002-0409-322X
Xueyan Wang *Department of Allergy, Beijing ShiJiTan Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0003-2267-2943
Zhenlin Wang *Department of Otorhinolaryngology Head and Neck Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0003-0948-7129
Qingyu Wei *Department of Allergy, Shengjing Hospital of China Medical University, Shenyang, China.ORCID https://orcid.org/0000-0002-5436-3494
Hua Xie *Department of Allergy, Northern Theatre General Hospital, Shenyang, China.ORCID https://orcid.org/0000-0003-4904-0698
Zhimin Xing *Department of Otolaryngology-Head and Neck Surgery, Peking University People's Hospital, Beijing, China.ORCID https://orcid.org/0000-0002-4325-9392
Rui Xu *Department of Allergy of Otorhinolaryngology Hospital, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.ORCID https://orcid.org/0000-0002-2065-6117
Yu Xu *Department of Otorhinolaryngology Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, China.ORCID https://orcid.org/0000-0001-7751-6345
Qintai Yang *Department of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.ORCID https://orcid.org/0000-0003-3377-737X
Hongmei Yao *Department of Respiratory and Critical Care Medicine, Guizhou Provincial People's Hospital, Guiyang, China.
Jing Ye *Department of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, China.ORCID https://orcid.org/0000-0002-1737-4573
Yiwen You *Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, China.ORCID https://orcid.org/0000-0002-4171-1621
Hongmeng Yu *Department of Otolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-2578-9103
Yongmei Yu *Department of Otorhinolaryngology, The First Affiliated Hospital of Kunming Medical University, Kunming, China.ORCID https://orcid.org/0000-0001-7394-8079
Huanping Zhang *Department of Allergy, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, China.ORCID https://orcid.org/0000-0003-2263-6774
Gehua Zhang *Department of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.ORCID https://orcid.org/0000-0002-1917-0283
Yuan Zhang *Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0003-1080-4267
Yuxiang Zhi *Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Weikang Zhou *Department of Allergy, Chongqing General Hospital, Chongqing, China.
Li Zhu *Department of Otorhinolaryngology, The Third Hospital of Peking University, Beijing, China.
Xinhua Zhu *Department of Otorhinolaryngology Head and Neck Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, China.ORCID https://orcid.org/0000-0002-3801-6329
Ruonan ChaiDepartment of Allergy, Northern Theatre General Hospital, Shenyang, China.
Dehua ChenDepartment of Allergy of Otorhinolaryngology Hospital, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Kai GuanDepartment of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.ORCID https://orcid.org/0000-0003-0850-5874
Zizhen HuangDepartment of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.ORCID https://orcid.org/0000-0001-6390-8508
Yanran HuangDepartment of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0001-5755-7684
Tingting MaDepartment of Allergy, Beijing ShiJiTan Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0002-8488-651X
Yuemei MaDepartment of Allergy, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Yifan MengDepartment of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0003-2988-8763
Lei RenDepartment of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0003-2490-1877
Jianxing WangDepartment of Otorhinolaryngology Head and Neck Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Nan WangDepartment of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.ORCID https://orcid.org/0000-0002-4109-8441
Mo XianDepartment of Allergy and Clinical Immunology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Rong XiangDepartment of Otorhinolaryngology Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
Ming ZhengDepartment of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0002-8991-6642
Luo ZhangDepartment of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0002-0910-9884
Chinese Society of Allergy (CSA) and Chinese Allergic Rhinitis Collaborative Research Group (C2AR2G)
Beijing Tongren Hospital · CNSun Yat-sen University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNBeijing Shijitan Hospital · CNEye & ENT Hospital of Fudan University · CNFirst Affiliated Hospital of Guangzhou Medical University · CNFujian Medical University · CNHebei Medical University · CNNanchang University · CNNorthern Hospital · AUPeking University · CNTongji Hospital · CNWuhan University · CNCapital Medical University · CNChina Medical University · CNFirst People's Hospital of Chongqing · CNGuangdong Academy of Medical Sciences · CNGuangxi Medical University · CNGuizhou Provincial People's Hospital · CNHarbin Medical University · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the last few decades, there has been a progressive increase in the prevalence of allergic rhinitis (AR) in China, where it now affects approximately 250 million people. AR prevention and treatment include allergen avoidance, pharmacotherapy, allergen immunotherapy (AIT), and patient education, among which AIT is the only curative intervention. AIT targets the disease etiology and may potentially modify the immune system as well as induce allergen-specific immune tolerance in patients with AR. In 2017, a team of experts from the Chinese Society of Allergy (CSA) and the Chinese Allergic Rhinitis Collaborative Research Group (C2AR2G) produced the first English version of Chinese AIT guidelines for AR. Since then, there has been considerable progress in basic research of and clinical practice for AIT, especially regarding the role of follicular regulatory T (TFR) cells in the pathogenesis of AR and the use of allergen-specific immunoglobulin E (sIgE) in nasal secretions for the diagnosis of AR. Additionally, potential biomarkers, including TFR cells, sIgG4, and sIgE, have been used to monitor the incidence and progression of AR. Moreover, there has been a novel understanding of AIT during the coronavirus disease 2019 pandemic. Hence, there was an urgent need to update the AIT guideline for AR by a team of experts from CSA and C2AR2G. This document aims to serve as professional reference material on AIT for AR treatment in China, thus improving the development of AIT across the world.
Indexed as
Allergen immunotherapyallergic rhinitisbiomarkersChinaguidelineshouse dust mitesimmunoglobulin Erush immunotherapysubcutaneous immunotherapy
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