Evidence map›Paper›PMID 36426360›Full record

ArticleFrontiers in immunology2022

A single birth dose of Hepatitis B vaccine induces polyfunctional CD4

Julia Strandmark, Alansana Darboe, Joann Diray-Arce, Rym Ben-Othman, Sofia M Vignolo, Shun Rao, Kinga K Smolen, Geert Leroux-Roels, Olubukola T Idoko, Guzmán Sanchez-Schmitz and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 5 countries.

Julia StrandmarkVaccines & Immunity Theme, Medical Research Council (MRC) Unit The Gambia at London School of Hygiene & Tropical Medicine (LSHTM), Fajara, Gambia.
Alansana DarboeVaccines & Immunity Theme, Medical Research Council (MRC) Unit The Gambia at London School of Hygiene & Tropical Medicine (LSHTM), Fajara, Gambia.
Joann Diray-ArcePrecision Vaccines Program, Boston Children's Hospital, Boston, MA, United States.
Rym Ben-OthmanDepartment of Paediatrics, University of British Columbia, Vancouver, BC, Canada.
Sofia M VignoloPrecision Vaccines Program, Boston Children's Hospital, Boston, MA, United States.
Shun RaoPrecision Vaccines Program, Boston Children's Hospital, Boston, MA, United States.
Kinga K SmolenPrecision Vaccines Program, Boston Children's Hospital, Boston, MA, United States.
Geert Leroux-RoelsCenter for Vaccinology, Ghent University Hospital, Ghent, Belgium.
Olubukola T IdokoVaccines & Immunity Theme, Medical Research Council (MRC) Unit The Gambia at London School of Hygiene & Tropical Medicine (LSHTM), Fajara, Gambia.
Guzmán Sanchez-SchmitzPrecision Vaccines Program, Boston Children's Hospital, Boston, MA, United States.
Al OzonoffPrecision Vaccines Program, Boston Children's Hospital, Boston, MA, United States.
Ofer LevyPrecision Vaccines Program, Boston Children's Hospital, Boston, MA, United States.
Tobias R KollmannDepartment of Paediatrics, University of British Columbia, Vancouver, BC, Canada.
Arnaud MarchantInstitute for Medical Immunology, Université Libre de Bruxelles, Brussels, Belgium.
Beate KampmannVaccines & Immunity Theme, Medical Research Council (MRC) Unit The Gambia at London School of Hygiene & Tropical Medicine (LSHTM), Fajara, Gambia.
Boston Children's Hospital · USMRC Unit the Gambia · GMHarvard University · USUniversity of British Columbia · CAGhent University Hospital · BEUniversité Libre de Bruxelles · BE

Funding

Transcriptomics to define biomarkers of neonatal vaccine immunogenicityU19AI118608 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI LEVY, OFER · 2017 to 2021
$24.7M
NIAID NIH HHS U19 AI118608
6 · The paper itself

Abstract

A single birth-dose of Hepatitis B vaccine (HepB) can protect newborns from acquiring Hepatitis B infection through vertical transmission, though several follow-up doses are required to induce long-lived protection. In addition to stimulating antibodies, a birth-dose of HepB might also induce polyfunctional CD4

Indexed as

Hepatitis B VaccinesLeukocytes, MononuclearCD4-Positive T-LymphocytesHumansInfantInfant, NewbornPhenylbutyratesT-Lymphocytes, Helper-Inducergamma-hydroxy-gamma-ethyl-gamma-phenylbutyramideHepatitis B VaccinesPhenylbutyratesantibody titresBCGCD154CD4 + T helper cellHepatitis B vaccineneonateT-cell activation

Identifiers

PMID36426360
PMCPMC9681035
OpenAlexW4308592508

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.