Evidence map›Paper›PMID 36426033›Full record

ArticleData in brief2022

Valorphins alter physicochemical characteristics of phosphatidylcholine membranes: Datasets on lipid packing, bending rigidity, specific electrical capacitance, dipole potential, vesicle size.

Victoria Vitkova, Galya Staneva, Rusina Hazarosova, Stela I Georgieva, Iva Valkova, Krassimira Antonova, Petаr Todorov

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Data in brief, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Impact of Truncated Oxidized Phosphatidylcholines on Phospholipase AInternational journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Victoria VitkovaInstitute of Solid State Physics, Bulgarian Academy of Sciences, 72 Tzarigradsko Chaussee Blvd., 1784 Sofia, Bulgaria.
Galya StanevaInstitute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., bl. 21, Sofia 1113, Bulgaria.
Rusina HazarosovaInstitute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., bl. 21, Sofia 1113, Bulgaria.
Stela I GeorgievaDepartment of Analytical Chemistry, University of Chemical Technology and Metallurgy, 8 Kliment Ohridski Blvd., 1756 Sofia, Bulgaria.
Iva ValkovaDepartment of Chemistry, Faculty of Pharmacy, Medical University, 2 Dunav Str. 1000 Sofia, Bulgaria.
Krassimira AntonovaInstitute of Solid State Physics, Bulgarian Academy of Sciences, 72 Tzarigradsko Chaussee Blvd., 1784 Sofia, Bulgaria.
Petаr TodorovDepartment of Organic Chemistry, University of Chemical Technology and Metallurgy, 8 Kliment Ohridski Blvd., 1756 Sofia, Bulgaria.
Georgi Nadjakov Institute of Solid State Physics · BGInstitute of Biophysics and Biomedical Engineering · BGUniversity of Chemical Technology and Metallurgy · BGMedical University of Sofia · BG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endogenous hemorphins are being intensively investigated as therapeutic agents in neuropharmacology, and also as biomarkers in mood regulation, inflammation and oncology. The datasets collected herein report physicochemical parameters of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine membranes in the presence of VV-hemorphin-5 (Val-Val-Tyr-Pro-Trp-Thr-Gln) and analogues, modified at position 1 and 7 by the natural amino acid isoleucine or the non-proteinogenic 2-aminoisobutyric, 2,3-diaminopropanoic or 2,4-diaminobutanoic amino acids. These peptides have been previously screened for nociceptive activity and were chosen accordingly. The present article contains fluorescence spectroscopy data of Laurdan- and di-8-ANEPPS- labelled large unilamellar vesicles (LUV) providing the degree of hydration and dipole potential of lipid bilayers in the presence of VV-hemorphin-5 analogues. Lipid packing is accessible from Laurdan intensity profiles and generalized polarization datasets reported herein. The data presented on fluorescence intensity ratios of di-8-ANEPPS dye provide dipole potential values of phosphatidylcholine-valorphin membranes. Vesicle size and electrophoretic mobility datasets included refer to the effect of valorphins on the size distribution and

Indexed as

Aib, 2-aminoisobutyric acidCV, cyclic voltammetryDab, 2,4-diaminobutanoic acidDap, 2,3-diaminopropanoic acidDi-8-ANEPPSDi-8-ANEPPS, 4-(2-[6-(Dioctylamino)-2-naphthalenyl]ethenyl)-1-(3-sulfopropyl)pyridinium inner saltDPV, differential pulse voltammetryFluctuation analysisGln, glutamine (Q)GP, generalized polarizationGUV, giant unilamellar vesicleIle, isoleucine (I)Isothermal titration calorimetryITC, isothermal titration calorimetryITO, indium tin oxideLaurdanLipid vesiclesLUV, large unilamellar vesiclePC, phosphatidylcholinePDMS, polydimethylsiloxanePOPC, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholinePro, proline (P)Thr, threonine (T)Trp, tryptophan (W)Tyr, tyrosine (Y)Val, valine (V)VoltammetryVV-hemorphin-5, Val-Val-Tyr-Pro-Trp-Thr-Gln-NH2АTSF, analysis of thermal shape fluctuations

Identifiers

PMID36426033
PMCPMC9679672
OpenAlexW4308112123

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.