Evidence map›Paper›PMID 36425905›Full record

ArticleUrology case reports2022

Hyperprogressive disease after avelumab maintenance therapy in a patient with advanced ureter cancer: A case report.

Keita Ogasawara, Daiki Ikarashi, Shinji Tamada, Takashi Tsuyukubo, Hiromitsu Fujisawa, Wataru Obara

Open access · goldAbstract readCase Reports
In one paragraph

Article in Urology case reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Keita OgasawaraDepartment of Urology, Iwate Prefectural Central Hospital 4-1, Ueda, Morioka-shi, Iwate, 020-0066, Japan.
Daiki IkarashiDepartment of Urology, Iwate Prefectural Central Hospital 4-1, Ueda, Morioka-shi, Iwate, 020-0066, Japan.
Shinji TamadaDepartment of Urology, Iwate Prefectural Central Hospital 4-1, Ueda, Morioka-shi, Iwate, 020-0066, Japan.
Takashi TsuyukuboDepartment of Urology, Iwate Prefectural Central Hospital 4-1, Ueda, Morioka-shi, Iwate, 020-0066, Japan.
Hiromitsu FujisawaDepartment of Urology, Iwate Prefectural Central Hospital 4-1, Ueda, Morioka-shi, Iwate, 020-0066, Japan.
Wataru ObaraDepartment of Urology, Iwate Medical University School of Medicine, 2-1-1, Yahaba, Shiwa-gun, Iwate, 028-3695, Japan.
Iwate Prefectural Central Hospital · JPIwate Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the early stages of immunocheckpoint inhibitor administration, we should be aware of rapid cancer progression, known as hyperprogressive disease, in real-world clinical practice. We report a case of a 73-year-old man who presented with right abdominal pain and was diagnosed with advanced right ureteral cancer involving the duodenum. He received four cycles of chemotherapy with gemcitabine plus cisplatin, followed by maintenance with avermab. After two cycles of avermab within a month, his primary cancer dramatically progressed and he died. This is the first report of a case in which unresectable ureteral cancer caused hyperprogressive disease after avelumab maintenance therapy.

Indexed as

AvelumabHyperprogressive diseaseMaintenanceOS, Ovarall SurvivalPFS, Progressin Free SurvivalUreteral cancerUrothelial carcinoma

Identifiers

PMID36425905
PMCPMC9679574
OpenAlexW4307935841

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.