Evidence map›Paper›PMID 36425870›Full record

ArticleEClinicalMedicine2023

Effects of pharmacotherapy on sleep-related outcomes in adults with chronic low back pain: A systematic review and meta-analysis of randomised controlled trials.

Emma A Craige, Scott D Tagliaferri, Sally A Ferguson, Hannah Scott, Daniel L Belavy, Dayna F Easton, Paul Buntine, Aamir R Memon, Patrick J Owen, Grace E Vincent

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EClinicalMedicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Emma A CraigeSchool of Medical and Applied Sciences, Central Queensland University, Rockhampton, Queensland, Australia.
Scott D TagliaferriInstitute for Physical Activity and Nutrition (IPAN), Deakin University, Geelong, Victoria, Australia.
Sally A FergusonAppleton Institute, School of Medical and Applied Sciences, Central Queensland University, South Australia, Australia.
Hannah ScottFlinders Health and Medical Research Institute: Sleep Health, Flinders University, Adelaide, Australia.
Daniel L BelavyDepartment of Applied Health Sciences, Hochschule für Gesundheit, Bochum, Germany.
Dayna F EastonAppleton Institute, School of Medical and Applied Sciences, Central Queensland University, South Australia, Australia.
Paul BuntineEastern Health Clinical School, Monash University, Melbourne, Australia.
Aamir R MemonInstitute for Health and Sport, Victoria University, Melbourne, Australia.
Patrick J OwenInstitute for Physical Activity and Nutrition (IPAN), Deakin University, Geelong, Victoria, Australia.
Grace E VincentAppleton Institute, School of Medical and Applied Sciences, Central Queensland University, South Australia, Australia.
Central Queensland University · AUDeakin University · AUEastern Health · AUFlinders University · AUHochschule für Gesundheit - University of Applied Sciences · DEVictoria University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Adults with chronic low back pain (CLBP) suffer impaired sleep. Medications for CLBP can impact sleep which in turn may influence treatment outcomes. This systematic review and meta-analysis examined the effects of pharmacotherapy (any type) on sleep in adults with CLBP. Methods: In this systematic review and meta-analysis, we searched PubMed, CINAHL, SPORTDiscus, PsycINFO, EMBASE, and CENTRAL from inception to 10 July 2022. Randomised controlled trials that investigated the effects of pharmacotherapy on sleep in adults with CLBP were included. Manual citation search of relevant systematic reviews and included studies were also conducted. Mean change from baseline for sleep outcomes (e.g., sleep quality, total sleep time, wake after sleep onset) was the effect of interest. Pairwise inverse-variance random effect meta-analysis was performed to impute pooled estimates (Hedges' g or risk ratios). The Hartung-Knapp-Sidik-Jonkman method was used where there were ≤5 studies. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system was used for evaluating the certainty of evidence. This study was registered with PROSPERO (CRD42022309419). Findings: Assessment of 3959 records resulted in nine studies (n = 2927) being included. Pharmacotherapy for CLBP management had a small, yet unlikely clinically significant, effect on improving sleep in adults with CLBP, when compared to placebo (g [95% CI]: -0.23 [-0.37, -0.09], Interpretation: Pharmacotherapy used to manage CLBP provided improvements in sleep in adults with CLBP. Given that these effects were small and unlikely clinically significant, clinicians could consider alternative treatments (e.g., non-pharmacological interventions) for managing sleep in adults with CLBP. However, low to very low certainty of evidence precluded strong conclusions. To improve certainty of evidence and confidence in the effect estimates, future research needs to use robust method to minimise bias. Additional research evaluating multiple sleep characteristics, using both validated objective and subjective measures, is also warranted to further investigate the influence of distinct sleep parameters. Funding: The Summer Research Scholarship from the Appleton Institute, Central Queensland University, Australia.

Indexed as

Low back painMeta-analysisPharmacotherapySleepSystematic review

Identifiers

PMID36425870
PMCPMC9678954
OpenAlexW4309241735

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.