Permissive and nonpermissive channel closings in CFTR revealed by a factor graph inference algorithm.

Alexander S Moffett, Guiying Cui, Peter J Thomas, William D Hunt, Nael A McCarty, Ryan S Westafer, Andrew W Eckford

Open access · goldAbstract read

In one paragraph

Article in Biophysical reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.1field-weighted citation impact, top 56% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Alexander S MoffettDepartment of Electrical Engineering and Computer Science, York University, Toronto, ON, Canada.

Guiying CuiEmory + Children's Center for Cystic Fibrosis and Airways Disease Research, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia.

Peter J ThomasDepartment of Mathematics, Applied Mathematics, and Statistics, Case Western Reserve University, Cleveland, Ohio.

William D HuntSchool of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, Georgia.

Nael A McCartyEmory + Children's Center for Cystic Fibrosis and Airways Disease Research, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia.

Ryan S WestaferGeorgia Tech Research Institute, Atlanta, Georgia.

Andrew W EckfordDepartment of Electrical Engineering and Computer Science, York University, Toronto, ON, Canada.

Emory University · USGeorgia Institute of Technology · USYork University · CACase Western Reserve University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The closing of the gated ion channel in the cystic fibrosis transmembrane conductance regulator can be categorized as nonpermissive to reopening, which involves the unbinding of ADP or ATP, or permissive, which does not. Identifying the type of closing is of interest as interactions with nucleotides can be affected in mutants or by introducing agonists. However, all closings are electrically silent and difficult to differentiate. For single-channel patch-clamp traces, we show that the type of the closing can be accurately determined by an inference algorithm implemented on a factor graph, which we demonstrate using both simulated and lab-obtained patch-clamp traces.

Identifiers

PMID36425670

DOI10.1016/j.bpr.2022.100083

PMCPMC9680790

OpenAlexW4306770764

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.