Evidence map›Paper›PMID 36425564›Full record

ReviewFrontiers in oncology2022

Latest updates on cellular and molecular biomarkers of gliomas.

Maroun Bou Zerdan, Ali Atoui, Ali Hijazi, Lynn Basbous, Reine Abou Zeidane, Saada M Alame, Hazem I Assi

Abstract readReview
In one paragraph

Review in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Maroun Bou ZerdanDepartment of Internal Medicine, State University of New York (SUNY) Upstate Medical University, Syracuse, NY, United States.
Ali AtouiHematology-Oncology Division, Internal Medicine Department, American University of Beirut Medical Center, Beirut, Lebanon.
Ali HijaziHematology-Oncology Division, Internal Medicine Department, American University of Beirut Medical Center, Beirut, Lebanon.
Lynn BasbousHematology-Oncology Division, Internal Medicine Department, American University of Beirut Medical Center, Beirut, Lebanon.
Reine Abou ZeidaneHematology-Oncology Division, Internal Medicine Department, American University of Beirut Medical Center, Beirut, Lebanon.
Saada M AlameDepartment of Pediatrics, Faculty of Medicine, Lebanese University, Beirut, Lebanon.
Hazem I AssiHematology-Oncology Division, Internal Medicine Department, American University of Beirut Medical Center, Beirut, Lebanon.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gliomas are the most common central nervous system malignancies, compromising almost 80% of all brain tumors and is associated with significant mortality. The classification of gliomas has shifted from basic histological perspective to one that is based on molecular biomarkers. Treatment of this type of tumors consists currently of surgery, chemotherapy and radiation therapy. During the past years, there was a limited development of effective glioma diagnostics and therapeutics due to multiple factors including the presence of blood-brain barrier and the heterogeneity of this type of tumors. Currently, it is necessary to highlight the advantage of molecular diagnosis of gliomas to develop patient targeted therapies based on multiple oncogenic pathway. In this review, we will evaluate the development of cellular and molecular biomarkers for the diagnosis of gliomas and the impact of these diagnostic tools for better tailored and targeted therapies.

Indexed as

biomarkerscirculating tumor cellscirculating tumor DNAgliomasimmune microenvironment

Identifiers

PMID36425564
PMCPMC9678906

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.