Evidence map›Paper›PMID 36425495›Full record

ArticleChemical science2022

Surfactant-chaperoned donor-acceptor-donor NIR-II dye strategy efficiently circumvents intermolecular aggregation to afford enhanced bioimaging contrast.

Tianyang Han, Yajun Wang, Jiajun Xu, Ningning Zhu, Lang Bai, Xiangping Liu, Bin Sun, Chenlong Yu, Qinglun Meng, Jiaqi Wang and 6 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 17 citations in OpenAlex.

  1. An ultra-small organic dye nanocluster for enhancing NIR-II imaging-guided surgery outcomes.European journal of nuclear medicine and molecular imaging · 2024
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Tianyang HanState Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University Changchun 130012 P. R. China sjzhu@jlu.edu.cn.
Yajun WangState Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University Changchun 130012 P. R. China sjzhu@jlu.edu.cn.
Jiajun XuState Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University Changchun 130012 P. R. China sjzhu@jlu.edu.cn.
Ningning ZhuState Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University Changchun 130012 P. R. China sjzhu@jlu.edu.cn.
Lang BaiState Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University Changchun 130012 P. R. China sjzhu@jlu.edu.cn.
Xiangping LiuState Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University Changchun 130012 P. R. China sjzhu@jlu.edu.cn.
Bin SunState Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University Changchun 130012 P. R. China sjzhu@jlu.edu.cn.
Chenlong YuState Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University Changchun 130012 P. R. China sjzhu@jlu.edu.cn.ORCID https://orcid.org/0000-0003-0667-2572
Qinglun MengState Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University Changchun 130012 P. R. China sjzhu@jlu.edu.cn.
Jiaqi WangState Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University Changchun 130012 P. R. China sjzhu@jlu.edu.cn.
Qi SuState Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University Changchun 130012 P. R. China sjzhu@jlu.edu.cn.
Qing CaiHospital of Stomatology, Jilin University Changchun 130021 P. R. China.
Kenneth S HettieMolecular Imaging Program at Stanford (MIPS), Department of Radiology, Stanford University School of Medicine Stanford California 94305 USA.ORCID https://orcid.org/0000-0002-0607-7944
Yuewei ZhangSchool of Chemistry and Pharmaceutical Engineering, Jilin Institute of Chemical Technology Jilin 132022 P. R. China.ORCID https://orcid.org/0000-0001-6696-0336
Shoujun ZhuState Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University Changchun 130012 P. R. China sjzhu@jlu.edu.cn.
Bai YangState Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University Changchun 130012 P. R. China sjzhu@jlu.edu.cn.ORCID https://orcid.org/0000-0003-1939-6423
Jilin University · CNJilin University of Chemical Technology · CNStanford University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fluorescence emission in the near-infrared-II (NIR-II) optical window affords reduced autofluorescence and light scattering, enabling deep-tissue visualization for both disease detection and surgical navigation. Small-molecule NIR-II dyes are preferable for clinical bioimaging applications, as the flexibility in their molecular synthesis allows for precise control of their optical and pharmacokinetic properties. Among the various types of dye, donor-acceptor-donor-based (D-A-D) dyes demonstrate exceptional photostability, whereas the frequently used PEGylation approach does not keep their intrinsic brightness enough in water environments due to their inherent effect of self-assembly. Here, we demonstrate that the commercially-available surfactants can serve as a dispersant to prevent molecular aggregation of PEGylated D-A-D dyes. Due to the favorable energetics for co-assembly between D-A-D dyes and surfactants, the formed surfactant-chaperoned dye strategy dramatically increases dye brightness. Accordingly, this effect provides remarkably improved performance for

Identifiers

PMID36425495
PMCPMC9667954
OpenAlexW4310334344

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.