Evidence map›Paper›PMID 36425405›Full record

ReviewTherapeutic advances in gastroenterology2022

The role of the gut microbiome in colonization resistance and recurrent

Anna Maria Seekatz, Nasia Safdar, Sahil Khanna

Open access · goldAbstract readReview
In one paragraph

Review in Therapeutic advances in gastroenterology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 1 pooled it
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.

  1. Alternative treatment of recurrentFrontiers in microbiology · 2024
    Pooled it
  2. Trial
  3. Impact of a Purified Microbiome Therapeutic on Abundance of Antimicrobial Resistance Genes in Patients With Recurrent Clostridioides difficile Infection.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Trial
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  17. Gut Microbiome Recovery inDiseases (Basel, Switzerland) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Anna Maria SeekatzDepartment of Biological Sciences, Clemson University, Clemson, SC, USA.
Nasia SafdarUniversity of Wisconsin, Madison, WI, USA.
Sahil KhannaDivision of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.ORCID https://orcid.org/0000-0002-7619-8338
Clemson University · USMayo Clinic · USUniversity of Wisconsin–Madison · US

Funding

Critical functions of the gut microbiota that mediate recovery from recurrent Clostridium difficile infectionK01DK111794 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SEEKATZ, ANNA MARIA · 2018 to 2022
$706k
NIDDK NIH HHS K01 DK111794
6 · The paper itself

Abstract

The species composition of the human gut microbiota is related to overall health, and a healthy gut microbiome is crucial in maintaining colonization resistance against pathogens. Disruption of gut microbiome composition and functionality reduces colonization resistance and has been associated with several gastrointestinal and non-gastrointestinal diseases. One prime example is Plain language summary:

Indexed as

bacteriaClostridioides difficile infectiondysbiosisfecal microbiota transplantationmicrobiotamicrobiota-based therapy

Identifiers

PMID36425405
PMCPMC9679343
OpenAlexW4310330215

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.