Evidence map›Paper›PMID 36425354›Full record

ArticleJournal of psychiatry and brain science2022

Structure, Function, and Genetics of the Cerebellum in Autism.

Lindsey M Sydnor, Kimberly A Aldinger

Registry-linked trialOpen access · diamondAbstract read
In one paragraph

Article in Journal of psychiatry and brain science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07098156 (Neuroanatomical Differences Associated With Anorexia Nervosa and Masking Behaviour in Autistic Individuals), which is not on this map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07098156 recruitingnot on this mapstarted 2025, after this paper: background citation

Neuroanatomical Differences Associated With Anorexia Nervosa and Masking Behaviour in Autistic Individuals

TypeobservationalSponsorUniversity of AberdeenRan2025 to 2026Enrolled50ConditionsAutism, Anorexia NervosaArmsSingle Research Visit 3T MRI Research Scan, Demographic and Behavioural Questionnaires
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
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  11. Social and emotional learning in the cerebellum.Nature reviews. Neuroscience · 2024
    Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Neuroanatomy of autism: what is the role of the cerebellum?Cerebral cortex (New York, N.Y. : 1991) · 2024
    Review
  18. Article
  19. Cognitive-Affective Functions of the Cerebellum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  20. The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Lindsey M SydnorCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, 98101, WA, USA.
Kimberly A AldingerCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, 98101, WA, USA.
Center for Infectious Disease Research · US

Funding

Mechanisms of Brain Dysmorphology in MN1 C-Terminal Truncation Syndrome, a Novel Intellectual Developmental Disability Disorder P50HD103524 · NICHD · UNIVERSITY OF WASHINGTON · PI DANIEL DOHERTY · 2020 to 2026
$9.9M
Mentored Career DevelopmentKL2TR001854 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Elizabeth Rhea Erwin Burner, Amy Elizabeth West · 2016 to 2026
$9.0M
Investigating the cellular and molecular neuropathology of the cerebellum in autismR21MH126244 · NIMH · SEATTLE CHILDREN'S HOSPITAL · PI ALDINGER, KIMBERLY ANNE · 2021 to 2022
$502k
NCATS NIH HHS KL2 TR001854NICHD NIH HHS P50 HD103524NIMH NIH HHS R21 MH126244
6 · The paper itself

Abstract

Autism spectrum disorders are common neurodevelopmental disorders that are defined by core behavioral symptoms but have diverse genetic and environmental risk factors. Despite its etiological heterogeneity, several unifying theories of autism have been proposed, including a central role for cerebellar dysfunction. The cerebellum follows a protracted course of development that culminates in an exquisitely crafted brain structure containing over half of the neurons in the entire brain densely packed into a highly organized structure. Through its complex network of connections with cortical and subcortical brain regions, the cerebellum acts as a sensorimotor regulator and affects changes in executive and limbic processing. In this review, we summarize the structural, functional, and genetic contributions of the cerebellum to autism.

Indexed as

autismcerebellumcytoarchitectureexcitatory inhibitory imbalancegeneticsPurkinje cells

Identifiers

PMID36425354
PMCPMC9683352
OpenAlexW4310458761

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.