Evidence map›Paper›PMID 36425303›Full record

ArticleThe journal of allergy and clinical immunology. Global2022

Phenotypic characterization of childhood- and adult-onset food allergy among adults in the United States.

Haley Hultquist, Ashley Dyer, Jialing Jiang, Ruchi Gupta, Christopher Warren

Open access · goldAbstract read
In one paragraph

Article in The journal of allergy and clinical immunology. Global, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Age-dependent differences in anaphylaxis: elderly population.Current opinion in allergy and clinical immunology · 2025
    Review
  8. Article
  9. Food allergies in older people: An emerging health problem.The World Allergy Organization journal · 2024
    Review
  10. Legume Allergens Pea, Chickpea, Lentil, Lupine and Beyond.Current allergy and asthma reports · 2024
    Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Haley HultquistCenter for Food Allergy and Asthma Research, Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago.
Ashley DyerCenter for Food Allergy and Asthma Research, Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago.
Jialing JiangCenter for Food Allergy and Asthma Research, Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago.
Ruchi GuptaCenter for Food Allergy and Asthma Research, Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago.
Christopher WarrenCenter for Food Allergy and Asthma Research, Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago.
Northwestern University · US

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
FORWARD Supplement Standardizing EHR Data CollectionR01AI130348 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Ruchi S Gupta · 2017 to 2026
$10.9M
Intervention to Reduce Early (Peanut) Allergy in Children (iREACH)U01AI138907 · NIAID · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI GUPTA, RUCHI S · 2019 to 2023
$8.0M
US Prevalence, Distribution and Determinants of Adult and Childhood Food AllergyR21AI135702 · NIAID · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI GUPTA, RUCHI S · 2018 to 2019
$433k
NCATS NIH HHS UL1 TR001422NIAID NIH HHS R01 AI130348NIAID NIH HHS R21 AI135702NIAID NIH HHS U01 AI138907
6 · The paper itself

Abstract

Background: Food allergy (FA) affects ~10% of adults; however, little is known about the extent to which FA phenotypes and psychosocial burden vary depending on timing of allergy onset, whether in childhood or as an adult. Objective: This study explored FA characteristics according to timing of FA onset in US adults. Methods: Between 2015 and 2016, a cross-sectional survey was administered to 40,443 US adults. Complex survey-weighted results were tabulated across key demographic and clinical strata. Linear regression models explored covariate-adjusted variability in FA-related psychosocial burden across 3 groups: (1) adults solely with childhood-onset FA, (2) adults solely with adult-onset FA, and (3) adults with both childhood- and adult-onset FA. Results: Adults with both childhood- and adult-onset FAs, compared to adults with solely childhood- or adult-onset FAs, are significantly more likely to have severe FAs (57.3%, 52.6%, 43.2%), physician-diagnosed FAs (54.2%, 52.4%, 33.0%), and multiple FAs (74.8%, 41.0%, 30.3%) ( Conclusion: Differences exist in reaction severity, health care utilization, atopic comorbidities, and psychosocial burden according to the timing of FA onset. Future research exploring the heterogeneity of phenotypic expressions of adult FA may inform underlying mechanisms.

Indexed as

adult food allergyadult-onsetcomorbiditiesFood allergyhealth care utilizationprevalencequality of lifeseverity

Identifiers

PMID36425303
PMCPMC9683432
OpenAlexW4290851787

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.