Evidence map›Paper›PMID 36425206›Full record

ArticleRSC advances2022

Design, synthesis, theoretical study, antioxidant, and anticholinesterase activities of new pyrazolo-fused phenanthrolines.

Efraín Polo-Cuadrado, Cristian Rojas-Peña, Karen Acosta-Quiroga, Lorena Camargo-Ayala, Iván Brito, Jonathan Cisterna, Félix Moncada, Jorge Trilleras, Yeray A Rodríguez-Núñez, Margarita Gutierrez

Open access · goldAbstract read
In one paragraph

Article in RSC advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Chilean papaya (Heliyon · 2024
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Efraín Polo-CuadradoLaboratorio Síntesis Orgánica y Actividad Biológica (LSO-Act-Bio), Instituto de Química de Recursos Naturales, Universidad de Talca Casilla 747 Talca 3460000 Chile epolo@utalca.cl mgutierrez@utalca.cl.ORCID https://orcid.org/0000-0003-2280-9321
Cristian Rojas-PeñaLaboratorio Síntesis Orgánica y Actividad Biológica (LSO-Act-Bio), Instituto de Química de Recursos Naturales, Universidad de Talca Casilla 747 Talca 3460000 Chile epolo@utalca.cl mgutierrez@utalca.cl.
Karen Acosta-QuirogaLaboratorio Síntesis Orgánica y Actividad Biológica (LSO-Act-Bio), Instituto de Química de Recursos Naturales, Universidad de Talca Casilla 747 Talca 3460000 Chile epolo@utalca.cl mgutierrez@utalca.cl.
Lorena Camargo-AyalaDoctorado en Ciencias Mención I + D de Productos Bioactivos, Instituto de Química de Recursos Naturales, Laboratorio de Síntesis Orgánica (LSO-Act-Bio), Universidad de Talca Casilla 747 Talca 3460000 Chile.
Iván BritoDepartamento de Química, Facultad de Ciencias Básicas, Universidad de Antofagasta, Avda., Campus Coloso Antofagasta 02800 Chile.ORCID https://orcid.org/0000-0001-6077-2457
Jonathan CisternaDepartamento de Química, Facultad de Ciencias Básicas, Universidad de Antofagasta, Avda., Campus Coloso Antofagasta 02800 Chile.
Félix MoncadaDepartamento de Química, Universidad Nacional de Colombia Av. Cra 30 # 45-03 Bogotá Colombia.
Jorge TrillerasGrupo de Investigación en Compuestos Heterocíclicos, Universidad del Atlántico Puerto Colombia 081007 Colombia.ORCID https://orcid.org/0000-0002-4516-213X
Yeray A Rodríguez-NúñezDepartamento de Química, Facultad de Ciencias Exactas, Universidad Andrés Bello Republica 275 Santiago 8370146 Chile.ORCID https://orcid.org/0000-0003-4935-876X
Margarita GutierrezLaboratorio Síntesis Orgánica y Actividad Biológica (LSO-Act-Bio), Instituto de Química de Recursos Naturales, Universidad de Talca Casilla 747 Talca 3460000 Chile epolo@utalca.cl mgutierrez@utalca.cl.ORCID https://orcid.org/0000-0001-9153-2448
University of Talca · CLUniversidad de Antofagasta · CLUniversidad Andrés Bello · CLUniversidad Nacional de Colombia · COUniversity of Atlántico · CO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pyrazole-fused phenanthroline compounds were obtained through several synthetic routes. NMR, HRMS, and IR techniques were used to characterize and confirm the chemical structures. Crystal structures were obtained from compounds 3a, 5b, 5j, 5k, and 5n and analyzed using X-ray diffraction. Compounds were evaluated as acetyl (AChE) and butyrylcholinesterase (BChE) inhibitors, and the results showed a moderate activity. Compound 5c presented the best activity against AChE (IC

Identifiers

PMID36425206
PMCPMC9671100
OpenAlexW4310329765

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.