ArticleJournal of inflammation research2022
Studies on HBcAg-rBlo t 5-21 Fusion Protein Vaccine That Alleviates
Article in Journal of inflammation research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Multi-country IgE reactivity determination of isoforms of theFrontiers in immunology · 2026Article
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: In tropical and subtropical areas, allergens from the dust mite species Aim: To generate a chimeric virus-like particle containing HBcAg, Blo t 5 and Blo t 21 that can treat allergies caused by Methods: To produce allergic asthma in mice, prokaryotic expression and purification of Results: In allergy-induced mouse model experiments, the fusion allergen rBlo t 5-21 was more effective than the individual allergens rBlo t 5 and rBlo t 21 at inducing allergy. We found that vaccinating allergic mice with the recombinant fusion protein vaccine HBcAg-rBlo t 5-21 alleviated allergy symptoms elicited by the rBlo t 5-21 allergen. Vaccination with HBcAg-rBlo t 5-21 resulted in a decrease in total serum IgE levels, suppression of anaphylaxis, and reduction of inflammatory cell infiltration into lung tissue as compared to the PBS group. Conclusion: HBcAg-rBlo t 5-21, a protein vaccine containing both the hepatitis B core antigen and the
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