Evidence map›Paper›PMID 36424840›Full record

SynthesisInternational wound journal2023

A meta-analysis examined the effect of intrawound vancomycin on surgical site wound infections in non-spinal neurosurgical operation.

Xiangwu Zeng, Bo Yang, Baiming Zhang, Buxuan Xu, Congxue Rong, Jianhu She, Wanliang Guo, Jianlong Kong, Yangzi Liu, Dianfan Zhao and 1 more

RetractedOpen access · goldAbstract readReviewMeta-AnalysisRetracted Publication
In one paragraph

Synthesis in International wound journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Xiangwu ZengDepartment of Brain, The Second People's Hospital of Zhangye City, Zhangye, Gansu, China.
Bo YangDepartment of Pharmacy, The Second People's Hospital of Zhangye City, Zhangye, Gansu, China.
Baiming ZhangDepartment of Pharmacy, The Second People's Hospital of Zhangye City, Zhangye, Gansu, China.
Buxuan XuDepartment of Brain, The Second People's Hospital of Zhangye City, Zhangye, Gansu, China.
Congxue RongDepartment of Brain, The Second People's Hospital of Zhangye City, Zhangye, Gansu, China.
Jianhu SheDepartment of Brain, The Second People's Hospital of Zhangye City, Zhangye, Gansu, China.
Wanliang GuoDepartment of Brain, The Second People's Hospital of Zhangye City, Zhangye, Gansu, China.
Jianlong KongDepartment of Brain, The Second People's Hospital of Zhangye City, Zhangye, Gansu, China.
Yangzi LiuDepartment of Brain, The Second People's Hospital of Zhangye City, Zhangye, Gansu, China.
Dianfan ZhaoDepartment of Brain, The Second People's Hospital of Zhangye City, Zhangye, Gansu, China.
Xiuzhen XuDepartment of Pharmacy, The Second People's Hospital of Zhangye City, Zhangye, Gansu, China.ORCID https://orcid.org/0000-0003-1940-768X
Hexi University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To assess the impact of intrawound vancomycin on surgical site wound infections in non-spinal neurosurgical operations, we conducted a meta-analysis. A thorough review of the literature up to September 2022 showed that 4286 participants had a non-spinal neurosurgical operation at the start of the investigations; 1975 of them used intrawound vancomycin, while 2311 were control. Using dichotomous or contentious methods and a random or fixed-effect model, odds ratios (OR) and mean difference (MD) with 95% confidence intervals (CIs) were estimated to evaluate the impact of intrawound vancomycin on surgical site wound infections in non-spinal neurosurgical operation. The intrawound vancomycin had significantly lower surgical site wound infections (OR, 0.28; 95% CI, 0.19-0.40; P < .001) with low heterogeneity (I2 = 32%) compared with the control in non-spinal neurosurgical operation. The intrawound vancomycin had significantly lower surgical site wound infections compared with control in non-spinal neurosurgical operation. The low sample size of 2 out of 13 researches in the meta-analysis calls for care when analysing the results.

Indexed as

Anti-Bacterial AgentsVancomycinHumansOdds RatioSurgical Wound InfectionAnti-Bacterial AgentsVancomycinintrawound vancomycinnon-spinal neurosurgical operationsurgical site wound infections

Identifiers

PMID36424840
PMCPMC10088818
OpenAlexW4309933535

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.