Evidence map›Paper›PMID 36424678›Full record

ArticleJACC. Clinical electrophysiology2022

Outcome of New-Onset Postoperative Atrial Fibrillation After Cardiac Surgery in Adults With Congenital Heart Disease.

Alexander C Egbe, William R Miranda, Jason H Anderson, Christopher V DeSimone, Kartik Andi, Ahmed Y Goda, Elizabeth H Stephens, Joseph A Dearani, Juan Crestanello, Heidi M Connolly and 1 more

Open access · greenAbstract read
In one paragraph

Article in JACC. Clinical electrophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Alexander C EgbeDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA. Electronic address: egbe.alexander@mayo.edu.
William R MirandaDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Jason H AndersonDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Christopher V DeSimoneDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Kartik AndiDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Ahmed Y GodaDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Elizabeth H StephensDepartment of Cardiovascular Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Joseph A DearaniDepartment of Cardiovascular Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Juan CrestanelloDepartment of Cardiovascular Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Heidi M ConnollyDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Abhishek J DeshmukhDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Mayo Clinic · US

Funding

Mechanisms of Clinical and Hemodynamic Response to Pulmonary Vasodilator Therapy in Fontan physiologyR01HL160761 · NHLBI · MAYO CLINIC ROCHESTER · PI Alexander Egbe · 2022 to 2026
$3.1M
Pathophysiologic Mechanism for Arrhythmias and Impaired Aerobic Capacity in Tetralogy of FallotR01HL158517 · NHLBI · MAYO CLINIC ROCHESTER · PI EGBE, ALEXANDER · 2021 to 2025
$2.9M
Ventricular and Pulmonary Vascular Reserve after the Fontan OperationK23HL141448 · NHLBI · MAYO CLINIC ROCHESTER · PI EGBE, ALEXANDER · 2018 to 2021
$693k
NHLBI NIH HHS K23 HL141448NHLBI NIH HHS R01 HL158517NHLBI NIH HHS R01 HL160761
6 · The paper itself

Abstract

backgroundPostoperative atrial fibrillation (POAF) is one of the most common complications after cardiac surgery. POAF is associated with a longer hospital stay, higher healthcare resource utilization, and higher risk of morbidity and mortality. As a result, the American and European guidelines recommend the use of beta-blockers and amiodarone for the prevention of POAF, and in turn, avoid the complications associated with POAF.

objectivesThe purpose of this study was to determine the incidence, risk factors, and prognostic implications of new-onset POAF after cardiac surgery in adults with congenital heart disease (CHD).

methodsA retrospective study was conducted among adults with CHD who underwent cardiac surgery (2003-2019). POAF and late-onset atrial fibrillation (AF) were defined as AF occurring within and after 30 days postoperatively, respectively.

resultsOf 1,598 patients (mean age 39 ± 13 years, 51% men), 335 (21%) developed POAF. Risk factors associated with POAF were older age, hypertension, left atrial (LA) reservoir strain and right atrial (RA) dysfunction, and nonsystemic atrioventricular valve regurgitation. Of 1,291 patients (81%) with follow-up ≥12 months, the annual incidence of late-onset AF was 1.5% and was higher in patients with POAF compared with those without POAF (5.9% vs 0.4%; P < 0.001). Risk factors associated with late-onset AF were POAF, older age, severe CHD, and LA and RA dysfunction. Of the 1,291 patients, 63 (5%) died during follow-up, and the risk factors associated with all-cause mortality were older age, severe CHD, hypertension, left ventricular systolic dysfunction, and LA and RA dysfunction. POAF was not associated with all-cause mortality.

conclusionsPOAF was common in adults with CHD and was associated with late-onset AF but not all-cause mortality. Atrial dysfunction was independently associated with POAF, late-onset AF, and all-cause mortality. These risk factors can be used to identify patients at risk for POAF and provide a foundation for prospective studies assessing the efficacy of prophylactic therapies in this population.

Indexed as

Atrial FibrillationCardiac Surgical ProceduresHeart Defects, CongenitalHypertensionAdultFemaleHumansMaleMiddle AgedPostoperative ComplicationsProspective StudiesRetrospective Studiesatrial dysfunctionatrial fibrillationprognostication

Identifiers

PMID36424678
PMCPMC9991111
OpenAlexW4307956619

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.