Evidence map›Paper›PMID 36424652›Full record

ArticleJournal of neuroengineering and rehabilitation2022

Triple tSMS system ("SHIN jiba") for non-invasive deep brain stimulation: a validation study in healthy subjects.

Sumiya Shibata, Tatsunori Watanabe, Takuya Matsumoto, Keisuke Yunoki, Takayuki Horinouchi, Hikari Kirimoto, Jianxu Zhang, Hen Wang, Jinglong Wu, Hideaki Onishi and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroengineering and rehabilitation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 2 countries.

Sumiya ShibataDepartment of Physical Therapy, Niigata University of Health and Welfare, 1398 Shimami-Cho, Kita-Ku, Niigata-Shi, Niigata, 950-3198, Japan. sumiya-shibata@nuhw.ac.jp.
Tatsunori WatanabeFaculty of Health Sciences, Aomori University of Health and Welfare, 58-1 Mase, Hamadate, Aomori, 030-8505, Japan.
Takuya MatsumotoDepartment of Sensorimotor Neuroscience, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8553, Japan.
Keisuke YunokiDepartment of Sensorimotor Neuroscience, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8553, Japan.
Takayuki HorinouchiDepartment of Sensorimotor Neuroscience, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8553, Japan.
Hikari KirimotoDepartment of Sensorimotor Neuroscience, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8553, Japan.
Jianxu ZhangSchool of Mechatronical Engineering, Beijing Institute of Technology, No. 5 South Street, Zhongguancun, Haidian, Beijing, 100081, China.
Hen WangQingdao Medical College, Qingdao University, 308 Ning Xia Lu, Laoshan, Qingdao, 266071, Shandong, China.
Jinglong WuSchool of Mechatronical Engineering, Beijing Institute of Technology, No. 5 South Street, Zhongguancun, Haidian, Beijing, 100081, China.
Hideaki OnishiDepartment of Physical Therapy, Niigata University of Health and Welfare, 1398 Shimami-Cho, Kita-Ku, Niigata-Shi, Niigata, 950-3198, Japan.
Tatsuya MimaThe Graduate School of Core Ethics and Frontier Sciences, Ritsumeikan University, 56-1, Tojiin, Kitamachi, Kita-Ku, Kyoto, 603-8577, Japan.
Hiroshima University · JPNiigata University of Health and Welfare · JPAomori University of Health and Welfare · JPBeijing Institute of Technology · CNOkayama University · JPQingdao University · CNRitsumeikan University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTranscranial static magnetic field stimulation (tSMS) using a small and strong neodymium (NdFeB) magnet can temporarily suppress brain functions below the magnet. It is a promising non-invasive brain stimulation modality because of its competitive advantages such as safety, simplicity, and low-cost. However, current tSMS is insufficient to effectively stimulate deep brain areas due to attenuation of the magnetic field with the distance from the magnet. The aim of this study was to develop a brand-new tSMS system for non-invasive deep brain stimulation.

methodsWe designed and fabricated a triple tSMS system with three cylindrical NdFeB magnets placed close to each other. We compared the strength of magnetic field produced by the triple tSMS system with that by the current tSMS. Furthermore, to confirm its function, we stimulated the primary motor area in 17 healthy subjects with the triple tSMS for 20 min and assessed the cortical excitability using the motor evoked potential (MEP) obtained by transcranial magnetic stimulation.

resultsOur triple tSMS system produced the magnetic field sufficient for neuromodulation up to 80 mm depth from the magnet surface, which was 30 mm deeper than the current tSMS system. In the stimulation experiment, the triple tSMS significantly reduced the MEP amplitude, demonstrating a successful inhibition of the M1 excitability in healthy subjects.

conclusionOur triple tSMS system has an ability to produce an effective magnetic field in deep areas and to modulate the brain functions. It can be used for non-invasive deep brain stimulation.

Indexed as

Deep Brain StimulationTranscranial Magnetic StimulationEvoked Potentials, MotorHealthy VolunteersHumansMagnetic FieldsDeep brain stimulationNeodymium magnetNon-invasive brain stimulationSHIN jibaTranscranial static magnetic field stimulation

Identifiers

PMID36424652
PMCPMC9694846
OpenAlexW4309905413

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.