ArticleBMC medicine2022
Interactions among maternal smoking, breastfeeding, and offspring genetic factors on the risk of adult-onset hypertension.
Article in BMC medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Association of Smoking, Smoking Cessation, and Genetic Susceptibility With Chronic Kidney Disease Risk.Kidney medicine · 2026Article
- Prevalence of undiagnosed hypertension and risk assessment using a validated survey in community-based screening in Amman, Jordan.PloS one · 2026Article
- Breastfeeding, genetic susceptibility, and type 2 diabetes in offspring in later life.Obesity (Silver Spring, Md.) · 2025Article
- Longitudinal association of cumulative risk factors in early life, genetic risk, and healthy lifestyles during adulthood with the risk of type 2 diabetes.BMC medicine · 2025Article
- Association of maternal smoking, breastfeeding, and multiple birth with irritable bowel syndrome in older adults: a UK Biobank cohort study.Gastroenterology report · 2025Article
- Causal Associations Between Obstructive Sleep Apnea and Hypertension: Evidence From a Bidirectional and Multivariable Mendelian Randomization Analysis.International journal of hypertension · 2025Article
- The association between maternal smoking during pregnancy and multimorbidity of non-communicable chronic diseases trajectory in offspring.BMC public health · 2024Article
- Multifaceted paternal exposures before conception and their epigenetic impact on offspring.Journal of assisted reproduction and genetics · 2024Review
- Article
- Maternal smoking, nutritional factors at different life stage, and the risk of incident type 2 diabetes: a prospective study of the UK Biobank.BMC medicine · 2024Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundPrevious studies have reported that maternal smoking during pregnancy and breastfeeding may affect the occurrence of hypertension, but whether early life factors modify the impact of the offspring's genetic risk on hypertension is still unknown. The aim of this study was to investigate the relationships among maternal smoking and breastfeeding with adult-onset hypertension and the modified impact of offspring genetic susceptibility.
methodsThis study included 437,185 participants from the UK Biobank who were initially free of hypertension and provided a prospective cohort of individuals aged 40 to 69 years. The association of maternal smoking during pregnancy and breastfeeding with hypertension was examined by using the Cox regression model. Then, a polygenic risk score (PRS) for hypertension was used to test the gene-environmental interaction on hypertension.
resultsDuring a median follow-up period of 8.7 years, a total of 68,148 cases of hypertension were identified in this study. The hazard ratios (HRs) and 95% confidence intervals (CIs) of hypertension for maternal smoking and breastfeeding were 1.11 (1.09, 1.13) and 0.96 (0.94, 0.98), respectively. However, no evidence of an interaction between maternal smoking and breastfeeding was observed. Across all levels of genetic risk, including high genetic risk, maternal smoking and nonbreastfeeding had higher hypertension hazards than nonmaternal smoking and breastfeeding, respectively. The adjusted HRs (95% CIs) of hypertension were 1.80 (1.73, 1.87) in those who had high genetic predisposition plus maternal smoking and 1.67 (1.60-1.74) in those with nonbreastfeeding and high genetic risk. There were significant additive interactions between maternal smoking or breastfeeding and genetic factors on the incidence of hypertension.
conclusionsMaternal smoking and nonbreastfeeding were associated with a higher risk of hypertension in adulthood and may attenuate the risk of hypertension related to genetic factors. These results suggested that adherence to nonmaternal smoking and breastfeeding was associated with a lower risk of hypertension among participants with all gradients of genetic risk.
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