ArticleBMC pregnancy and childbirth2022
Association between isolated maternal hypothyroxinemia during the first trimester and adverse pregnancy outcomes in Southern Chinese women: a retrospective study of 7051 cases.
Article in BMC pregnancy and childbirth, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- The Effect of Iron and Iodine on the Association Between Particular Matter 2.5 and Thyroid Function in the First Trimester of Pregnancy.Biological trace element research · 2026Article
- Thyroid markers in early to mid-pregnancy and risk of gestational diabetes: a longitudinal retrospective cohort study.Frontiers in endocrinology · 2026Article
- The association of early pregnancy, particularly persistent isolated maternal hypothyroxinemia, with adverse obstetric and perinatal outcomes.BMC pregnancy and childbirth · 2025Article
- Free thyroxine modifying the association of serum ferritin with gestational diabetes risk: A retrospective cohort study.Nutrition journal · 2025Article
- Development and validation of a prediction nomogram for adverse pregnancy outcomes among urban Chinese women with hypothyroxinemia during early pregnancy.BMC pregnancy and childbirth · 2025Article
- Maternal obesity and the incidence of large-for-gestational-age newborns in isolated hypothyroxinemia pregnancies: a comparative cohort study.Reproductive biology and endocrinology : RB&E · 2025Article
- First-trimester thyroid reference intervals in twin pregnancy: establishment, diagnostic utility, and association with adverse outcomes.Frontiers in endocrinology · 2025Article
- Predictive value of thyroid hormone levels for postpartum hemorrhage in hypothyroidism-complicated pregnancy.Frontiers in endocrinology · 2025Article
- Development of an animal model of hypothyroxinemia during pregnancy in Wistar rats.Animal models and experimental medicine · 2024Article
- Article
- Maternal isolated hypothyroxinemia in the first trimester is not associated with adverse pregnancy outcomes, except for macrosomia: a prospective cohort study in China.Frontiers in endocrinology · 2023Article
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Authors and funding
7 authors at 1 institution in 1 country.
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Abstract
backgroundThe association between isolated maternal hypothyroxinemia (IMH) and adverse pregnancy outcomes is still controversial. This study aimed to evaluate the association between IMH during the first trimester and adverse pregnancy outcomes in southern Chinese women.
methodsThis was a hospital-based, retrospective cohort study. The records of 7051 women, including 1337 IMH women and 5714 euthyroid women who had a singleton pregnancy and accepted routine prenatal service at the Third Affiliated Hospital of Sun Yat-Sen University from January 2015 to September 2018, were extracted from the electronic medical records system in this study. Thyroid functions [thyroid-stimulating hormone (TSH), free thyroxine (fT4) and anti-thyroperoxidase autoantibody (TPO-Ab)] had to be measured before 13 weeks and 6 days of gestation. The chi-square test and multivariate logistic regression analysis were applied to evaluate the association between IMH during the first trimester and adverse pregnancy outcomes.
resultsPrepregnancy obesity [prepregnancy body mass index (preBMI) ≥ 25 kg/m
conclusionIMH during the first trimester did not increase any risk of adverse pregnancy outcomes in southern Chinese women except LGA.
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