ArticleNature neuroscience2022
TDP-43 condensates and lipid droplets regulate the reactivity of microglia and regeneration after traumatic brain injury.
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Article in Nature neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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42citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
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Who cites it
42 citing papers in PubMed, 55 citations in OpenAlex.
- Lipophagy and lipid droplets in neurodegeneration.Trends in pharmacological sciences · 2026Review
- Tibial bone compression promotes recovery after brain injury through osteocyte PIEZO1.Nature neuroscience · 2026Article
- Distinct Transcriptional States of TDP-43 Pathology in an Alzheimer's Disease Mouse Model.Neuroscience bulletin · 2026Article
- Acupuncture regulates mitochondrial homeostasis in traumatic brain injury: current evidence, mechanistic hypotheses, and translational challenges.Chinese medicine · 2026Review
- PLIN2-PGAM5-regulated lipid droplet-mitochondria contacts drive microglial neuroinflammation after spinal cord injury via fatty acid metabolic reprogramming.Cell death and differentiation · 2026Article
- Single-cell RNA sequencing in stroke and traumatic brain injury: Current achievements, challenges and future perspectives on transcriptomic profiling.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Review
- The microglia-derived protein Sema4ab attenuates regenerative neurogenesis after spinal cord injury in zebrafish.PLoS biology · 2026Article
- ABCA1-mediated lipid efflux restrains oxidative stress and neuroinflammation after spinal cord injury.Journal of neuroinflammation · 2026Article
- Signal control during tissue regeneration in adult animals.Nature reviews. Molecular cell biology · 2026Review
- Article
- Single-cell RNA sequencing uncovers molecular features underlying microglial lipid accumulation and depression-related behaviors in high-fat diet mouse model of obesity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Neuroimmune Microenvironment Reprogramming via Immuno-piezoelectric Transducers for Synergistic Stem Cell Therapy in Traumatic Brain Injury.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Compromised blood-brain barrier in traumatic brain injury model ofIranian journal of basic medical sciences · 2026Article
- Head trauma and environment progression of amyotrophic lateral sclerosis: long-term data from the National ALS Registry.BMJ neurology open · 2026Article
- Transferrin-phosphatidylserine liposomes target TDP-43 and neuroinflammation in male mice with neuropathic pain.Nature communications · 2025Article
- Polyhalogenated Carbazole Impairs Dopaminergic Neurons through Dysregulation of Liquid-Liquid Phase Separation in Caenorhabditis elegans.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Aging: the wound that never starts healing.Nature communications · 2025Review
- Ligustilide Ameliorates Traumatic Brain Injury in Aged Mice by Attenuating Microglia-Mediated Neuroinflammation.Neurochemical research · 2025Article
- Review
- Activated TBK1 promotes ACSL1-mediated microglia lipid droplet accumulation and neuroinflammation in Parkinson's disease.Journal of neuroinflammation · 2025Article
Corrections and comments
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Authors and funding
25 authors at 7 institutions in 1 country.
Alessandro Zambusi *Biomedical Center Munich (BMC), Department of Cell Biology and Anatomy, Medical Faculty, LMU, Munich, Germany.
Klara Tereza Novoselc *Biomedical Center Munich (BMC), Department of Cell Biology and Anatomy, Medical Faculty, LMU, Munich, Germany.
Saskia HuttenBiomedical Center Munich (BMC), Department of Cell Biology and Anatomy, Medical Faculty, LMU, Munich, Germany.
Sofia KalpazidouBiomedical Center Munich (BMC), Department of Cell Biology and Anatomy, Medical Faculty, LMU, Munich, Germany.
Christina KoupourtidouBiomedical Center Munich (BMC), Department of Cell Biology and Anatomy, Medical Faculty, LMU, Munich, Germany.ORCID http://orcid.org/0000-0002-8352-1498
Rico SchieweckBiomedical Center Munich (BMC), Department of Cell Biology and Anatomy, Medical Faculty, LMU, Munich, Germany.
Sven AschenbroichBiomedical Center Munich (BMC), Department of Cell Biology and Anatomy, Medical Faculty, LMU, Munich, Germany.
Lara SilvaBiomedical Center Munich (BMC), Department of Cell Biology and Anatomy, Medical Faculty, LMU, Munich, Germany.
Ayse Seda YazgiliComprehensive Pneumology Center (CPC), Institute of Lung Health and Immunity (LHI), Helmholtz Zentrum Munich, Munich, Germany.ORCID http://orcid.org/0000-0001-8485-9653
Frauke van BebberGerman Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
Bettina SchmidGerman Center for Neurodegenerative Diseases (DZNE), Munich, Germany.ORCID http://orcid.org/0000-0001-8043-7269
Gabriel MöllerImaging Core Facility, Biocenter, University of Würzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0002-8731-4330
Clara TritscherImaging Core Facility, Biocenter, University of Würzburg, Würzburg, Germany.
Christian StigloherImaging Core Facility, Biocenter, University of Würzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0001-6941-2669
Claire DelbridgeInstitute of Pathology, Faculty of Medicine, TUM, Munich, Germany.
Swetlana SirkoInstitute of Stem Cell Research, Helmholtz Zentrum Munich, Munich, Germany.ORCID http://orcid.org/0000-0001-5950-616X
Zeynep Irem GünesInstitute of Clinical Neuroimmunology, Klinikum der Universität München, LMU, Munich, Germany.
Sabine LiebscherInstitute of Clinical Neuroimmunology, Klinikum der Universität München, LMU, Munich, Germany.ORCID http://orcid.org/0000-0001-5633-8981
Jürgen SchlegelInstitute of Pathology, Faculty of Medicine, TUM, Munich, Germany.
Hananeh AlieeInstitute of Computational Biology, Helmholtz Zentrum Munich, Munich, Germany.
Fabian TheisInstitute of Computational Biology, Helmholtz Zentrum Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-2419-1943
Silke MeinersComprehensive Pneumology Center (CPC), Institute of Lung Health and Immunity (LHI), Helmholtz Zentrum Munich, Munich, Germany.
Michael KieblerBiomedical Center Munich (BMC), Department of Cell Biology and Anatomy, Medical Faculty, LMU, Munich, Germany.
Dorothee Dormann *Biomedical Center Munich (BMC), Department of Cell Biology and Anatomy, Medical Faculty, LMU, Munich, Germany.ORCID http://orcid.org/0000-0002-9260-2775
Jovica Ninkovic *Biomedical Center Munich (BMC), Department of Cell Biology and Anatomy, Medical Faculty, LMU, Munich, Germany. ninkovic@helmholtz-muenchen.de.ORCID http://orcid.org/0000-0002-4381-0041
Helmholtz Zentrum München · DELudwig-Maximilians-Universität München · DEJohannes Gutenberg University Mainz · DEUniversity of Würzburg · DEGerman Center for Neurodegenerative Diseases · DELMU Klinikum · DETechnical University of Munich · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
Decreasing the activation of pathology-activated microglia is crucial to prevent chronic inflammation and tissue scarring. In this study, we used a stab wound injury model in zebrafish and identified an injury-induced microglial state characterized by the accumulation of lipid droplets and TAR DNA-binding protein of 43 kDa (TDP-43)
Indexed as
Brain Injuries, TraumaticMicrogliaAnimalsDNA-Binding ProteinsHumansLipid DropletsRegenerationZebrafishDNA-Binding Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.