ArticleNature neuroscience2022
Multiregion transcriptomic profiling of the primate brain reveals signatures of aging and the social environment.
Open access · greenAbstract read
In one paragraph
Article in Nature neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 34 citations in OpenAlex.
- Feasibility of Field Oral Health Assessment in Free-Ranging Rhesus Macaques (Macaca mulatta) on Cayo Santiago.American journal of primatology · 2026Article
- Patterns of transcriptomic aging in the hippocampus of rhesus macaques highlight midlife transitions.GeroScience · 2026Article
- Article
- Primate gut microbiota induce evolutionarily salient changes in mouse neurodevelopment.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Astrocyte epigenetics in development, aging, and neurodegeneration: a DNA methylation perspective.Frontiers in molecular neuroscience · 2026Review
- Inflammatory mechanisms underlying early Alzheimer's disease pathology: evidence from the aging rhesus macaque brain.Frontiers in cellular neuroscience · 2026Review
- Single-cell, multi-region profiling of the macaque brain across the lifespan.bioRxiv : the preprint server for biology · 2025Article
- Biomarkers of ageing of humans and non-human primates.Nature reviews. Molecular cell biology · 2025Review
- A lifespan transcriptomic atlas of the human prefrontal cortex at single-cell resolution.medRxiv : the preprint server for health sciences · 2025Article
- Article
- Astrocytes in aging.Neuron · 2025Review
- Understanding age and society using natural populations.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Single-nucleus transcriptomic profiling of human orbitofrontal cortex reveals convergent effects of aging and psychiatric disease.Nature neuroscience · 2024Article
- Animal Models Relevant for Geroscience: Current Trends and Future Perspectives in Biomarkers, and Measures of Biological Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Review
- Evolutionary and biomedical implications of sex differences in the primate brain transcriptome.Cell genomics · 2024Article
- Aging, Race, and Health Disparities: Recommendations From the Research Centers Collaborative Network.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024Article
- The biology of aging in a social world: Insights from free-ranging rhesus macaques.Neuroscience and biobehavioral reviews · 2023Review
- A marmoset brain cell census reveals regional specialization of cellular identities.Science advances · 2023Article
- A single-cell multi-omic atlas spanning the adult rhesus macaque brain.Science advances · 2023Article
- The impact of life stress on hallmarks of aging and accelerated senescence: Connections in sickness and in health.Neuroscience and biobehavioral reviews · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
32 authors at 15 institutions in 5 countries.
Kenneth L Chiou *Center for Evolution and Medicine, Arizona State University, Tempe, AZ, USA. chiou@asu.edu.ORCID http://orcid.org/0000-0001-7247-4107
Alex R DeCasien *Department of Anthropology, New York University, New York, NY, USA. alex.decasien@nyu.edu.
Katherina P ReesSchool of Life Sciences, Arizona State University, Tempe, AZ, USA.
Camille TestardDepartment of Neuroscience, University of Pennsylvania, Philadelphia, PA, USA.
Cailyn H SpurrellBrotman Baty Institute for Precision Medicine, Seattle, WA, USA.
Aishwarya A GogateBrotman Baty Institute for Precision Medicine, Seattle, WA, USA.
Hannah A PlinerBrotman Baty Institute for Precision Medicine, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-1484-6501
Sébastien TremblayDepartment of Neuroscience, University of Pennsylvania, Philadelphia, PA, USA.
Arianne MercerDepartment of Psychology, University of Washington, Seattle, WA, USA.
Connor J WhalenDepartment of Anthropology, New York University, New York, NY, USA.
Josué E Negrón-Del ValleSchool of Life Sciences, Arizona State University, Tempe, AZ, USA.
Mareike C JaniakSchool of Science, Engineering, & Environment, University of Salford, Salford, UK.ORCID http://orcid.org/0000-0002-7759-2556
Samuel E Bauman SurrattCaribbean Primate Research Center, University of Puerto Rico, San Juan, PR, USA.
Olga GonzálezSouthwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA.
Nicole R CompoCaribbean Primate Research Center, University of Puerto Rico, San Juan, PR, USA.
Michala K StockDepartment of Sociology and Anthropology, Metropolitan State University of Denver, Denver, CO, USA.
Angelina V Ruiz-LambidesCaribbean Primate Research Center, University of Puerto Rico, San Juan, PR, USA.
Melween I MartínezCaribbean Primate Research Center, University of Puerto Rico, San Juan, PR, USA.
Cayo Biobank Research Unit
Melissa A WilsonCenter for Evolution and Medicine, Arizona State University, Tempe, AZ, USA.
Amanda D MelinDepartment of Anthropology and Archaeology, University of Calgary, Calgary, Alberta, Canada.ORCID http://orcid.org/0000-0002-0612-2514
Susan C AntónDepartment of Anthropology, New York University, New York, NY, USA.ORCID http://orcid.org/0000-0003-2253-6650
Christopher S WalkerDepartment of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.
Jérôme SalletStem Cell and Brain Research Institute, Université Lyon, Lyon, France.
Jason M NewbernSchool of Life Sciences, Arizona State University, Tempe, AZ, USA.
Lea M StaritaBrotman Baty Institute for Precision Medicine, Seattle, WA, USA.
Jay ShendureBrotman Baty Institute for Precision Medicine, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-1516-1865
James P HighamDepartment of Anthropology, New York University, New York, NY, USA.
Lauren J N BrentCentre for Research in Animal Behaviour, University of Exeter, Exeter, UK.ORCID http://orcid.org/0000-0002-1202-1939
Michael J MontagueDepartment of Neuroscience, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-0253-4404
Michael L PlattDepartment of Neuroscience, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-3912-8821
Noah Snyder-MacklerCenter for Evolution and Medicine, Arizona State University, Tempe, AZ, USA. nsnyderm@asu.edu.ORCID http://orcid.org/0000-0003-3026-6160
Arizona State University · USUniversity of Pennsylvania · USUniversity of Puerto Rico System · PRUniversity of Washington · USBrotman Baty Institute · USNew York Consortium in Evolutionary Primatology · USHoward Hughes Medical Institute · USMetropolitan State University of Denver · USNew York University · USNorth Carolina State University · USTexas Biomedical Research Institute · USUniversité Claude Bernard Lyon 1 · FRUniversity of Calgary · CAUniversity of Exeter · GBUniversity of Salford · GB
Funding
Vascular Structure and Function in Cognitive AgingP01AG003949 · NIA · YESHIVA UNIVERSITY · PI CHRISTOPHER G ENGELAND · 1985 to 2026
$73.9MAlzheimer's Disease Genetics ConsortiumU01AG032984 · NIA · UNIVERSITY OF PENNSYLVANIA · PI SCHELLENBERG, GERARD DAVID · 2009 to 2024
$60.4MSUPPLEMENT TO ALZHEIMERS DISEASE PATIENT REGISTRYU01AG006786 · NIA · MAYO CLINIC ROCHESTER · PI GRAFF-RADFORD, JONATHAN, JACK, CLIFFORD R. · 1986 to 2023
$49.6MSUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI LEURGANS, SUE E. · 1991 to 2020
$49.1MEPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3MTranslational Science InitiativeP40OD012217 · OD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI CARLOS A SARIOL · 2012 to 2026
$40.4MTHE PGRN/TDP-43 AXIS IN ALZHEIMER?S DISEASE AND NEURODEGENERATIONP50AG016574 · NIA · MAYO CLINIC ROCHESTER · PI PETERSEN, RONALD C · 1999 to 2018
$36.9MResearch Education ComponentP30AG019610 · NIA · SUN HEALTH RESEARCH INSTITUTE · PI REIMAN, ERIC MICHAEL · 2001 to 2020
$32.5MIntegrating the exposome and methylome to inform brain molecular changes in ADRD across established diverse cohorts.U01AG046139 · NIA · UNIVERSITY OF FLORIDA · PI ERTEKIN-TANER, NILUFER, FUNK, CORY · 2013 to 2022
$24.6MRISK FACTORS, PATHOLOGY, AND CLINICAL EXPRESSIONS OF ADR01AG015819 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1998 to 2024
$21.4MGENETIC APPROACHES TO AGING RESEARCHT32AG000057 · NIA · UNIVERSITY OF WASHINGTON · PI RABINOVITCH, PETER S · 1985 to 2019
$14.2MMulti-omic network-directed proteoform discovery, dissection and functional validation to prioritize novel AD therapeutic targetsU01AG061356 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BENNETT, DAVID ALAN, DE JAGER, PHILIP L · 2018 to 2022
$13.7MCCR NIH HHS HHSN261200800001CNCI NIH HHS HHSN261200800001ENHLBI NIH HHS HHSN268201000029CNIA NIH HHS K99 AG075241NIA NIH HHS P01 AG003949NIA NIH HHS P01 AG017216NIA NIH HHS P30 AG010161NIA NIH HHS P30 AG019610NIA NIH HHS P50 AG016574NIA NIH HHS P50 AG025711NIA NIH HHS R00 AG051764NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG018023NIA NIH HHS R01 AG030146NIA NIH HHS R01 AG032990NIA NIH HHS R01 AG036042NIA NIH HHS R01 AG036836NIA NIH HHS R01 AG048015NIA NIH HHS R01 AG060931NIA NIH HHS RC2 AG036547NIA NIH HHS RF1 AG057473NIA NIH HHS T32 AG000057NIA NIH HHS U01 AG006786NIA NIH HHS U01 AG032984NIA NIH HHS U01 AG046139NIA NIH HHS U01 AG046152NIA NIH HHS U01 AG046161NIA NIH HHS U01 AG061356NIDA NIH HHS R01 DA006227NIGMS NIH HHS R35 GM124827NIH HHS P40 OD012217NIMH NIH HHS R01 MH090936NIMH NIH HHS R01 MH090937NIMH NIH HHS R01 MH090941NIMH NIH HHS R01 MH090948NIMH NIH HHS R01 MH090951NIMH NIH HHS R01 MH096875NIMH NIH HHS R01 MH101782NIMH NIH HHS R01 MH101810NIMH NIH HHS R01 MH101814NIMH NIH HHS R01 MH101819NIMH NIH HHS R01 MH101820NIMH NIH HHS R01 MH101822NIMH NIH HHS R01 MH101825NIMH NIH HHS R01 MH118203NIMH NIH HHS U01 MH121260NINDS NIH HHS R01 NS080820NINDS NIH HHS R01 NS097537NINDS NIH HHS U24 NS072026U.S. Department of Health & Human Services | NIH | National Center for Research Resources (NCRR) P40OD012217U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R35GM124827U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH096875U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH118203U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) U01MH121260U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS097537U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) R00AG051764U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) R01AG060931U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) T32AG000057
Abstract
Aging is accompanied by a host of social and biological changes that correlate with behavior, cognitive health and susceptibility to neurodegenerative disease. To understand trajectories of brain aging in a primate, we generated a multiregion bulk (N = 527 samples) and single-nucleus (N = 24 samples) brain transcriptional dataset encompassing 15 brain regions and both sexes in a unique population of free-ranging, behaviorally phenotyped rhesus macaques. We demonstrate that age-related changes in the level and variance of gene expression occur in genes associated with neural functions and neurological diseases, including Alzheimer's disease. Further, we show that higher social status in females is associated with younger relative transcriptional ages, providing a link between the social environment and aging in the brain. Our findings lend insight into biological mechanisms underlying brain aging in a nonhuman primate model of human behavior, cognition and health.
Indexed as
Neurodegenerative DiseasesAgingAnimalsFemaleHumansMacaca mulattaMaleSocial EnvironmentSolitary NucleusTranscriptome
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.