ArticleNature2022
MYC multimers shield stalled replication forks from RNA polymerase.
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Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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0cells of the map it votes in
49citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 87 citations in OpenAlex.
- Targeting MYC-Driven Cancers: From Oncogenic Addiction to Therapeutic Vulnerability.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026Review
- ATR activity regulates DNA replication and RNA polymerase II transcription during S-phase.iScience · 2026Article
- A functional landscape for chromosome 17q in neuroblastoma: balancing replication stress and genomic stability.British journal of cancer · 2026Review
- Targeting MYCN Degradation by HLB-0532259 Induces Senescence in Retinoblastoma.Investigative ophthalmology & visual science · 2026Article
- MYC serine 62 phosphorylation promotes its association with DNA double-strand breaks to facilitate repair and cell survival under genotoxic stress.Genes & development · 2026Article
- Article
- Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stability.Molecular cell · 2026Article
- WDR5 remodels NANOG condensates to drive transcriptional programs and sustain stem cell identity.Nature communications · 2026Article
- CDK12 and CDK13 in oncology: from RNA regulation to therapeutic targeting.Cellular oncology (Dordrecht, Netherlands) · 2026Review
- KCTD10 as a selective cancer dependency from transcription-replication conflicts (TRCs).Ageing and cancer research & treatment · 2026Article
- MYC drives left-handed Z-DNA formation to shape gene expression.Nature communications · 2025Article
- Transcriptional condensates and the nuclear pore complex regulate gene expression and 3D genome architecture in response to stress.Biochemical Society transactions · 2025Review
- PNMA1 mediates melphalam chemoresistance in retinoblastoma via promoting DNA repair.Scientific reports · 2025Article
- Phosphorylated Toll-like receptor 3 nuclear translocation in cancer cell promotes metastasis and chemoresistance.Signal transduction and targeted therapy · 2025Article
- Integrative characterization of MYC RNA-binding function.Cell genomics · 2025Article
- GPO-VAE: modeling explainable gene perturbation responses utilizing GRN-aligned parameter optimization.Bioinformatics (Oxford, England) · 2025Article
- Targeting MYC: Multidimensional regulation and therapeutic strategies in oncology.Genes & diseases · 2025Review
- MYC: The Guardian of Its Own Chaos.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- The USP11/TCEAL1 complex promotes transcription elongation to sustain oncogenic gene expression in neuroblastoma.Genes & development · 2025Article
- NONO interacts with nuclear PKM2 and directs histone H3 phosphorylation to promote triple-negative breast cancer metastasis.Journal of experimental & clinical cancer research : CR · 2025Article
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Authors and funding
23 authors at 5 institutions in 2 countries.
Daniel Solvie *Department of Biochemistry and Molecular Biology, University of Würzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0003-4529-667X
Apoorva Baluapuri *Department of Biochemistry and Molecular Biology, University of Würzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0002-3723-7891
Leonie Uhl *Department of Biochemistry and Molecular Biology, University of Würzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0003-0288-2572
Daniel FleischhauerDepartment of Biochemistry and Molecular Biology, University of Würzburg, Würzburg, Germany.
Theresa EndresDepartment of Biochemistry and Molecular Biology, University of Würzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0002-7701-7965
Dimitrios PapadopoulosDepartment of Biochemistry and Molecular Biology, University of Würzburg, Würzburg, Germany.
Amel AzibaDepartment of Biochemistry and Molecular Biology, University of Würzburg, Würzburg, Germany.
Abdallah GaballaDepartment of Biochemistry and Molecular Biology, University of Würzburg, Würzburg, Germany.
Ivan MikicicInstitute of Molecular Biology (IMB), Mainz, Germany.ORCID http://orcid.org/0000-0003-3393-0688
Ekaterina IsaakovaInstitute of Molecular Biology (IMB), Mainz, Germany.
Celeste GiansantiInstitute of Molecular Oncology, Center of Molecular Biosciences, University of Göttingen, Göttingen, Germany.ORCID http://orcid.org/0000-0003-3229-8385
Jennifer JansenInstitute of Molecular Oncology, Center of Molecular Biosciences, University of Göttingen, Göttingen, Germany.
Marvin JungblutDepartment of Biophysics and Biotechnology, Biocenter, University of Würzburg, Würzburg, Germany.
Teresa KleinDepartment of Biophysics and Biotechnology, Biocenter, University of Würzburg, Würzburg, Germany.
Christina Schülein-VölkCore Unit High-Content Microscopy, Biocenter, University of Würzburg, Würzburg, Germany.
Hans MaricRudolf-Virchow-Center for Integrative and Translational Imaging, University of Würzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0002-2719-4752
Sören DooseDepartment of Biophysics and Biotechnology, Biocenter, University of Würzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0002-6983-1182
Markus SauerDepartment of Biophysics and Biotechnology, Biocenter, University of Würzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0002-1692-3219
Petra BeliInstitute of Molecular Biology (IMB), Mainz, Germany.ORCID http://orcid.org/0000-0001-9507-9820
Andreas RosenwaldInstitute of Pathology, University of Würzburg, Würzburg, Germany.
Matthias DobbelsteinInstitute of Molecular Oncology, Center of Molecular Biosciences, University of Göttingen, Göttingen, Germany.
Elmar WolfDepartment of Biochemistry and Molecular Biology, University of Würzburg, Würzburg, Germany. elmar.wolf@biozentrum.uni-wuerzburg.de.ORCID http://orcid.org/0000-0002-5299-6335
Martin EilersDepartment of Biochemistry and Molecular Biology, University of Würzburg, Würzburg, Germany. martin.eilers@biozentrum.uni-wuerzburg.de.ORCID http://orcid.org/0000-0002-0376-6533
University of Würzburg · DEUniversity of Göttingen · DEInstitute of Molecular Biology · DEHarvard University · USJohannes Gutenberg University Mainz · DE
Funding
European Research Council
Abstract
Oncoproteins of the MYC family drive the development of numerous human tumours
Indexed as
DNA-Directed RNA PolymerasesAtaxia Telangiectasia Mutated ProteinsBinding SitesBRCA1 ProteinChromatinDNA Breaks, Double-StrandedFanconi Anemia Complementation Group D2 ProteinHumansPromoter Regions, GeneticProto-Oncogene Proteins c-mycRNA, MessengerRNA Polymerase IIS PhaseTranscription, GeneticTumor Suppressor ProteinsUbiquitin-Protein LigasesAtaxia Telangiectasia Mutated ProteinsATR protein, humanBRCA1 ProteinBRCA1 protein, humanChromatinDNA-Directed RNA PolymerasesFANCD2 protein, humanFanconi Anemia Complementation Group D2 ProteinHUWE1 protein, humanMYC protein, humanProto-Oncogene Proteins c-mycRNA, MessengerRNA Polymerase IITumor Suppressor ProteinsUbiquitin-Protein Ligases
Identifiers
What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.