ArticleNature communications2022
Uptake mechanism of iron-phytosiderophore from the soil based on the structure of yellow stripe transporter.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 36 citations in OpenAlex.
- Folate transporters at the plasma membrane of fungi and plants: specificity, mechanism of transport, and importance.Biochemical Society transactions · 2026Review
- The transcription factor AtANAC070 enhances zinc tolerance by promoting AtMTP1 expression in Arabidopsis thaliana.Plant cell reports · 2026Article
- Transporter promiscuity and redox-driven metal partitioning in plant responses to chemically analogous metals.Plant cell reports · 2026Review
- Conformational Dynamics of NaJournal of chemical information and modeling · 2026Article
- Developmental stage-specific disruption of iron allocation by a ZmYSL2 mutation in maize.Planta · 2026Article
- Chelation-based iron uptake mitigates the effects of prolonged high-temperature stress in cool-season grasses.Nature communications · 2025Article
- ZmPRR37-ZmYSL14 module enhances salt stress tolerance in maize.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Enhancing Zinc Bioavailability in Rice Using the Novel Synthetic Siderophore Ligand Proline-2'-Deoxymugineic Acid (PDMA): Critical Insights from Metal Binding Studies and Geochemical Speciation Modeling.Journal of agricultural and food chemistry · 2025Article
- Brassinosteroids in Micronutrient Homeostasis: Mechanisms and Implications for Plant Nutrition and Stress Resilience.Plants (Basel, Switzerland) · 2025Review
- Structural determination of mugineic acid, an iron(III)-chelating substance secreted from graminaceous plants for efficient iron uptake.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2025Review
- PcWRKY1 Represses Transcription of Yellow Stripe-Like 3 (PcYSL3) to Negatively Regulate Radial Cadmium Transport in Poplar Stems.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Structural basis for antiepileptic drugs and botulinum neurotoxin recognition of SV2A.Nature communications · 2024Article
- Research progress on iron absorption, transport, and molecular regulation strategy in plants.Frontiers in plant science · 2023Review
- Iron sensing in plants.Frontiers in plant science · 2023Review
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calcareous soils cover one-third of all land and cause severe growth defects in plants due to the poor water solubility of iron at high pH. Poaceae species use a unique chelation strategy, whereby plants secrete a high-affinity metal chelator, known as phytosiderophores (mugineic acids), and reabsorb the iron-phytosiderophore complex by the yellow stripe 1/yellow stripe 1-like (YS1/YSL) transporter for efficient uptake of iron from the soil. Here, we present three cryo-electron microscopy structures of barley YS1 (HvYS1) in the apo state, in complex with an iron-phytosiderophore complex, Fe(III)-deoxymugineic acid (Fe(III)-DMA), and in complex with the iron-bound synthetic DMA analog (Fe(III)-PDMA). The structures reveal a homodimeric assembly mediated through an anti-parallel β-sheet interaction with cholesterol hemisuccinate. Each protomer adopts an outward open conformation, and Fe(III)-DMA is bound near the extracellular space in the central cavity. Fe(III)-PDMA occupies the same binding site as Fe(III)-DMA, demonstrating that PDMA can function as a potent fertilizer in an essentially identical manner to DMA. Our results provide a structural framework for iron-phytosiderophore recognition and transport by YS1/YSL transporters, which will enable the rational design of new, high-potency fertilizers.
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