Evidence map›Paper›PMID 36424374›Full record

ArticleNature communications2022

A class-mismatched TCR bypasses MHC restriction via an unorthodox but fully functional binding geometry.

Nishant K Singh, Jesus A Alonso, Jason R Devlin, Grant L J Keller, George I Gray, Adarsh K Chiranjivi, Sara G Foote, Lauren M Landau, Alyssa G Arbuiso, Laura I Weiss and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Ensembles ofbioRxiv : the preprint server for biology · 2026
    Article
  3. Review
  4. Deciphering Depigmentation: Mouse Models for Vitiligo Research.The Journal of investigative dermatology · 2025
    Review
  5. Article
  6. Review
  7. RankMHC: Learning to Rank Class-I Peptide-MHC Structural Models.Journal of chemical information and modeling · 2024
    Article
  8. Article
  9. Article
  10. T-cell virtuosity in ''knowing thyself".Frontiers in immunology · 2024
    Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Nishant K SinghDepartment of Chemistry & Biochemistry and the Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA.
Jesus A AlonsoDepartment of Chemistry & Biochemistry and the Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA.
Jason R DevlinDepartment of Chemistry & Biochemistry and the Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA.
Grant L J KellerDepartment of Chemistry & Biochemistry and the Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA.ORCID 0000-0001-7645-121X
George I GrayDepartment of Chemistry & Biochemistry and the Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA.
Adarsh K ChiranjiviDepartment of Chemistry & Biochemistry and the Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA.
Sara G FooteDepartment of Chemistry & Biochemistry and the Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA.
Lauren M LandauDepartment of Chemistry & Biochemistry and the Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA.ORCID 0000-0002-7980-7821
Alyssa G ArbuisoDepartment of Chemistry & Biochemistry and the Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA.
Laura I WeissDepartment of Chemistry & Biochemistry and the Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA.ORCID 0000-0002-6794-9187
Aaron M RosenbergDepartment of Chemistry & Biochemistry and the Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA.
Lance M HellmanDepartment of Chemistry & Biochemistry and the Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA.
Michael I NishimuraDepartment of Surgery, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, IL, USA.
Brian M BakerDepartment of Chemistry & Biochemistry and the Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA. brian-baker@nd.edu.ORCID 0000-0002-0864-0964
University of Notre Dame · USLoyola University Chicago · US

Funding

Structural biophysics and molecular design in cellular immunityR35GM118166 · NIGMS · UNIVERSITY OF NOTRE DAME · PI BAKER, BRIAN M · 2016 to 2025
$4.4M
NIGMS NIH HHS R35 GM118166U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R35GM118166
6 · The paper itself

Abstract

MHC restriction, which describes the binding of TCRs from CD4

Indexed as

CD8-Positive T-LymphocytesReceptors, Antigen, T-CellCell MembraneEngineeringHLA-A2 AntigenHLA-A2 AntigenReceptors, Antigen, T-Cell

Identifiers

PMID36424374
PMCPMC9691722
OpenAlexW4309900050

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.