ReviewNeurosurgery clinics of North America2023
Cerebrospinal Fluid Hydrodynamics in Chiari I Malformation and Syringomyelia: Modeling Pathophysiology.
Review in Neurosurgery clinics of North America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Thalidomide in Refractory Syringomyelia（RS）: a Phase II Clinical Trial
The Effect of Betaine in Refractory Syringomyelia（RS）
Subarachnoid-Subarachnoid (S-S) Bypass Versus Adhesion Lysis in Spinal Arachnoiditis and Syringomyelia
Who cites it
23 citing papers in PubMed, 31 citations in OpenAlex.
- Chiari I malformation.Nature reviews. Disease primers · 2026Review
- Pulsatile intraspinal pressure drives post-traumatic syringomyelia: evidence supporting the CSF pulsatile pressure dynamic equilibrium hypothesis.Fluids and barriers of the CNS · 2026Article
- Cervical syringomyelia presenting as isolated unilateral segmental myoclonus.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Cervicomedullary CSF space obliteration as a risk factor of reoperation in Chiari malformation type I.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- Bulbar "Red Flag" Symptoms and a 21-Year Diagnostic Delay in Adult Arnold-Chiari Type II Malformation With Tracheoesophageal Fistula and Syringomyelia: A Case Report.Clinical case reports · 2026Article
- Chiari malformation type 1 is associated with a smaller fourth ventricle volume - a multi-cohort replication study.Scientific reports · 2026Article
- MRI-morphometric characterization of Chiari malformation types 0 and 1 with syringomyelia: implications for diagnosis and pathogenesis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Observational
- The myodural bridge complex: a comprehensive review of morphology, physiology, developmental biology and pathology.Frontiers in medicine · 2026Review
- Tailoring the Surgical Approach to Chiari I Malformation with Intraoperative Ultrasounds: Advantages, Limitations, and Controversies.Pediatric neurosurgery · 2026Review
- Case Report: Reversible acquired Chiari-like state and upper cervical syringomyelia caused by a giant posterior tentorial tumor confined to the supratentorial compartment.Frontiers in surgery · 2026Article
- Cohort analysis of surgically managed Chiari malformation type 1: real-world data from multi-centres.Neurosurgical review · 2025Article
- Episodic Memory, Chiari I Malformation, Personality and Coping: The Role of Chronic Pain.Behavioral sciences (Basel, Switzerland) · 2025Review
- Idiopathic Syringomyelia: Diagnostic Value of Cranial Morphometric Parameters.Brain sciences · 2025Article
- Clinical phenotypes among patients with familial forms of Chiari malformation type 1.Journal of neurosurgery. Pediatrics · 2025Article
- Upper end of the central canal of the human spinal cord: Quantitative anatomical study and 3D modeling.Clinical anatomy (New York, N.Y.) · 2025Article
- Surgical Outcomes in Chiari 1 and Chiari 1.5 Malformation Treated by Posterior Fossa Reconstruction: A Comprehensive Analysis of 110 Pediatric Cases and Literature Review.Journal of clinical medicine · 2024Article
- Craniocervical instability in patients with Ehlers-Danlos syndromes: outcomes analysis following occipito-cervical fusion.Neurosurgical review · 2024Article
- Geometric morphometric analysis of the brainstem and cerebellum in Chiari I malformation.Frontiers in neuroanatomy · 2024Article
- Evaluation and Treatment of Patients with Small Posterior Cranial Fossa and Chiari Malformation, Types 0 and 1.Advances and technical standards in neurosurgery · 2024Article
- Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Anatomic MRI, MRI flow studies, and intraoperative ultrasonography demonstrate that the Chiari I malformation obstructs CSF pathways at the foramen magnum and prevents normal CSF movement through the foramen magnum. Impaired CSF displacement across the foramen magnum during the cardiac cycle increases pulsatile hindbrain motion, pressure transmission to the spinal subarachnoid space, and the amplitude of CSF subarachnoid pressure waves driving CSF into the spinal cord. Central canal septations in adults prevent syrinx formation by CSF directly transmitting its pressure wave from the fourth ventricle to the central canal.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.