Evidence map›Paper›PMID 36423925›Full record

ArticleThorax2023

Rebound in asthma exacerbations following relaxation of COVID-19 restrictions: a longitudinal population-based study (COVIDENCE UK).

Florence Tydeman, Paul E Pfeffer, Giulia Vivaldi, Hayley Holt, Mohammad Talaei, David Jolliffe, Gwyneth Davies, Ronan A Lyons, Christopher Griffiths, Frank Kee and 3 more

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Thorax, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04330599 (Longitudinal Population-based Observational Study of COVID-19 in the UK Population), which is not on this map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04330599 recruitingnot on this map

Longitudinal Population-based Observational Study of COVID-19 in the UK Population

TypeobservationalSponsorQueen Mary University of LondonRan2020 to 2026Enrolled13,000ConditionsCOVID-19
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Observational
  7. The role of innate immune system in respiratory viral infection related asthma.Frontiers in cellular and infection microbiology · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Florence TydemanBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Paul E PfefferWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0003-0369-2885
Giulia VivaldiBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Hayley HoltBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Mohammad TalaeiWolfson Institute of Population Health, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0002-6901-3665
David JolliffeBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0003-3592-1945
Gwyneth DaviesDepartment of Population Data Science, Swansea University Medical School, Swansea University, Swansea, UK.ORCID http://orcid.org/0000-0003-1218-1008
Ronan A LyonsDepartment of Population Data Science, Swansea University Medical School, Swansea University, Swansea, UK.ORCID http://orcid.org/0000-0001-5225-000X
Christopher GriffithsWolfson Institute of Population Health, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Frank KeeNorthern Health and Social Care Trust and Queens University Belfast, Queens University, Belfast, UK.ORCID http://orcid.org/0000-0002-0606-8167
Aziz SheikhUsher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-7022-3056
Seif O ShaheenWolfson Institute of Population Health, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0002-7273-8691
Adrian R MartineauBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK a.martineau@qmul.ac.uk.ORCID http://orcid.org/0000-0001-5387-1721
Queen Mary University of London · GBSwansea University · GBAsthma UK · GBQueen's University Belfast · GB

Funding

Medical Research Council MC_PC_19004
6 · The paper itself

Abstract

backgroundThe imposition of restrictions on social mixing early in the COVID-19 pandemic was followed by a reduction in asthma exacerbations in multiple settings internationally. Temporal trends in social mixing, incident acute respiratory infections (ARI) and asthma exacerbations following relaxation of COVID-19 restrictions have not yet been described.

methodsWe conducted a population-based longitudinal study in 2312 UK adults with asthma between November 2020 and April 2022. Details of face covering use, social mixing, incident ARI and severe asthma exacerbations were collected via monthly online questionnaires. Temporal changes in these parameters were visualised using Poisson generalised additive models. Multilevel logistic regression was used to test for associations between incident ARI and risk of asthma exacerbations, adjusting for potential confounders.

resultsRelaxation of COVID-19 restrictions from April 2021 coincided with reduced face covering use (p<0.001), increased frequency of indoor visits to public places and other households (p<0.001) and rising incidence of COVID-19 (p<0.001), non-COVID-19 ARI (p<0.001) and severe asthma exacerbations (p=0.007). Incident non-COVID-19 ARI associated independently with increased risk of asthma exacerbation (adjusted OR 5.75, 95% CI 4.75 to 6.97) as did incident COVID-19, both prior to emergence of the omicron variant of SARS-CoV-2 (5.89, 3.45 to 10.04) and subsequently (5.69, 3.89 to 8.31).

conclusionsRelaxation of COVID-19 restrictions coincided with decreased face covering use, increased social mixing and a rebound in ARI and asthma exacerbations. Associations between incident ARI and risk of severe asthma exacerbation were similar for non-COVID-19 ARI and COVID-19, both before and after emergence of the SARS-CoV-2 omicron variant. STUDY REGISTRATION NUMBER: NCT04330599.

Indexed as

AsthmaCOVID-19Respiratory Tract InfectionsAdultHumansLongitudinal StudiesPandemicsSARS-CoV-2United KingdomAsthmaCOVID-19

Identifiers

PMID36423925
PMCPMC10359556
OpenAlexW4310333363

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.