Evidence map›Paper›PMID 36423822›Full record

ArticleRespiratory physiology & neurobiology2023

Optogenetic activation of the tongue in spontaneously breathing mice.

Michele L Singer, Ethan S Benevides, Sabhya Rana, Michael D Sunshine, Robert C Martinez, Brian E Barral, Barry J Byrne, David D Fuller

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory physiology & neurobiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Michele L SingerRehabilitation Science PhD Program, University of Florida, 32611, the United States of America; Department of Physical Therapy, University of Florida, 32611, the United States of America; Breathing Research and Therapeutics Center, University of Florida, 32610, the United States of America; McKnight Brain Institute, 32610, University of Florida, the United States of America.
Ethan S BenevidesRehabilitation Science PhD Program, University of Florida, 32611, the United States of America; Department of Physical Therapy, University of Florida, 32611, the United States of America; Breathing Research and Therapeutics Center, University of Florida, 32610, the United States of America; McKnight Brain Institute, 32610, University of Florida, the United States of America.
Sabhya RanaDepartment of Physical Therapy, University of Florida, 32611, the United States of America; Breathing Research and Therapeutics Center, University of Florida, 32610, the United States of America; McKnight Brain Institute, 32610, University of Florida, the United States of America.
Michael D SunshineDepartment of Physical Therapy, University of Florida, 32611, the United States of America; Breathing Research and Therapeutics Center, University of Florida, 32610, the United States of America; McKnight Brain Institute, 32610, University of Florida, the United States of America.
Robert C MartinezMcKnight Brain Institute, 32610, University of Florida, the United States of America.
Brian E BarralMcKnight Brain Institute, 32610, University of Florida, the United States of America.
Barry J ByrneDepartment of Pediatrics, University of Florida, 32610, the United States of America; Powell Gene Therapy Center, University of Florida, 32610, the United States of America.
David D FullerDepartment of Physical Therapy, University of Florida, 32611, the United States of America; Breathing Research and Therapeutics Center, University of Florida, 32610, the United States of America; McKnight Brain Institute, 32610, University of Florida, the United States of America. Electronic address: ddf@phhp.ufl.edu.
University of Florida · USAllen Institute for Brain Science · US

Funding

Functional mapping of peripheral and central circuits for airway protection and breathingOT2OD023854 · OD · UNIVERSITY OF FLORIDA · PI BOLSER, DONALD C · 2016 to 2020
$10.8M
Control of Breathing & Glycogen Storage DiseaseR01HD052682 · NICHD · UNIVERSITY OF FLORIDA · PI BYRNE, BARRY J, FULLER, DAVID D · 2007 to 2024
$6.4M
NICHD NIH HHS R01 HD052682NIH HHS OT2 OD023854
6 · The paper itself

Abstract

Inadequate tongue muscle activation contributes to dysarthria, dysphagia, and obstructive sleep apnea. Thus, treatments which increase tongue muscle activity have potential clinical benefit. We hypothesized that lingual injection of an adeno-associated virus (AAV) encoding channelrhodopsin-2 (ChR2) would enable light-induced activation of tongue motor units during spontaneous breathing. An AAV serotype 9 vector (pACAGW-ChR2-Venus-AAV9, 8.29 × 10

Indexed as

OptogeneticsSleep Apnea, ObstructiveAnimalsMiceMice, Inbred C57BLRespirationTongueAdeno-associated virusChannelrhodopsinHypoglossalOptogeneticsTongue

Identifiers

PMID36423822
PMCPMC10167623
OpenAlexW4309763471

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.