Evidence map›Paper›PMID 36423815›Full record

ArticleJournal of vascular and interventional radiology : JVIR2023

MR Imaging-Based In Vivo Macrophage Imaging to Monitor Immune Response after Radiofrequency Ablation of the Liver.

Jessica G Santana, Alexandra Petukhova-Greenstein, Moritz Gross, Fahmeed Hyder, Vasily Pekurovsky, Luzie A Gottwald, Annemarie Boustani, John J Walsh, Ahmet S Kucukkaya, Rohil Malpani and 6 more

Open access · greenAbstract read
In one paragraph

Article in Journal of vascular and interventional radiology : JVIR, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 3 countries.

Jessica G SantanaDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut; Department of Biomedical Engineering, Yale University, New Haven, Connecticut.
Alexandra Petukhova-GreensteinDepartment of Radiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität, and Berlin Institute of Health, Berlin, Germany.
Moritz GrossDepartment of Radiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität, and Berlin Institute of Health, Berlin, Germany.
Fahmeed HyderDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut; Department of Biomedical Engineering, Yale University, New Haven, Connecticut.
Vasily PekurovskyDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut.
Luzie A GottwaldDepartment of Radiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität, and Berlin Institute of Health, Berlin, Germany.
Annemarie BoustaniDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut.
John J WalshDepartment of Biomedical Engineering, Yale University, New Haven, Connecticut.
Ahmet S KucukkayaDepartment of Radiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität, and Berlin Institute of Health, Berlin, Germany.
Rohil MalpaniDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut.
David C MadoffDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut.
S Nahum GoldbergDepartment of Radiology, Beth Israel Deaconess Medical Center, Harvard University, Boston, Massachusetts; Department of Radiology, Hadassah Hebrew University Medical Center, Jerusalem, Israel.
Muneeb AhmedDepartment of Radiology, Beth Israel Deaconess Medical Center, Harvard University, Boston, Massachusetts.
Nikhil JoshiDepartment of Immunobiology, Yale University School of Medicine, New Haven, Connecticut.
Daniel ComanDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut.
Julius ChapiroDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut. Electronic address: j.chapiro@googlemail.com.
Yale University · USHumboldt-Universität zu Berlin · DEBeth Israel Deaconess Medical Center · US

Funding

Yale Liver CenterP30DK034989 · NIDDK · YALE UNIVERSITY · PI YASUKO IWAKIRI · 1986 to 2026
$31.1M
Quantitative Multimodal Imaging Biomarkers for Combined Locoregional and Immunotherapy of Liver CancerR01CA206180 · NCI · YALE UNIVERSITY · PI CHAPIRO, JULIUS, DUNCAN, JAMES S · 2016 to 2025
$6.1M
Extracellular pH mapping as therapeutic readout of drug delivery in glioblastomaR01EB023366 · NIBIB · YALE UNIVERSITY · PI HYDER, DEWAN SYED FAHMEED · 2017 to 2020
$2.5M
NCI NIH HHS R01 CA206180NIBIB NIH HHS R01 EB023366NIDDK NIH HHS P30 DK034989
6 · The paper itself

Abstract

purposeTo establish molecular magnetic resonance (MR) imaging instruments for in vivo characterization of the immune response to hepatic radiofrequency (RF) ablation using cell-specific immunoprobes. MATERIALS AND

methodsSeventy-two C57BL/6 wild-type mice underwent standardized hepatic RF ablation (70 °C for 5 minutes) to generate a coagulation area measuring 6-7 mm in diameter. CD68

resultsRF ablation-induced periablational infiltration (206.92 μm ± 12.2) of CD68

conclusionsBoth SPION-enhanced T2

Indexed as

LiverRadiofrequency AblationAnimalsContrast MediaFerrocyanidesImmunityMacrophagesMagnetic Resonance ImagingMiceMice, Inbred C57BLContrast Mediaferric ferrocyanideFerrocyanides

Identifiers

PMID36423815
PMCPMC11042914
OpenAlexW4309764576

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.