Evidence map›Paper›PMID 36422959›Full record

ArticleToxins2022

Target Mechanisms of the Cyanotoxin Cylindrospermopsin in Immortalized Human Airway Epithelial Cells.

Sabine Ziesemer, Susann Meyer, Julia Edelmann, Janita Vennmann, Celine Gudra, Denise Arndt, Marcus Effenberg, Olla Hayas, Aref Hayas, Johanna Sophia Thomassen and 3 more

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 61% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Sabine ZiesemerAnimal Physiology and Biochemistry, University of Greifswald, Felix Hausdorff-Strasse 1, D-17489 Greifswald, Germany.ORCID 0000-0001-6055-6471
Susann MeyerFederal Institute for Occupational Safety and Occupational Medicine, Nöldnerstrasse 40-42, D-10317 Berlin, Germany.
Julia EdelmannAnimal Physiology and Biochemistry, University of Greifswald, Felix Hausdorff-Strasse 1, D-17489 Greifswald, Germany.
Janita VennmannAnimal Physiology and Biochemistry, University of Greifswald, Felix Hausdorff-Strasse 1, D-17489 Greifswald, Germany.
Celine GudraAnimal Physiology and Biochemistry, University of Greifswald, Felix Hausdorff-Strasse 1, D-17489 Greifswald, Germany.
Denise ArndtAnimal Physiology and Biochemistry, University of Greifswald, Felix Hausdorff-Strasse 1, D-17489 Greifswald, Germany.
Marcus EffenbergAnimal Physiology and Biochemistry, University of Greifswald, Felix Hausdorff-Strasse 1, D-17489 Greifswald, Germany.
Olla HayasAnimal Physiology and Biochemistry, University of Greifswald, Felix Hausdorff-Strasse 1, D-17489 Greifswald, Germany.
Aref HayasAnimal Physiology and Biochemistry, University of Greifswald, Felix Hausdorff-Strasse 1, D-17489 Greifswald, Germany.
Johanna Sophia ThomassenAnimal Physiology and Biochemistry, University of Greifswald, Felix Hausdorff-Strasse 1, D-17489 Greifswald, Germany.
Barbara KubickovaRECETOX, Faculty of Science, Masaryk University, Kotlarska 2, CZ-61137 Brno, Czech Republic.ORCID 0000-0002-5044-7180
Dierk-Christoph PötherFederal Institute for Occupational Safety and Occupational Medicine, Nöldnerstrasse 40-42, D-10317 Berlin, Germany.ORCID 0000-0001-7000-3520
Jan-Peter HildebrandtFederal Institute for Occupational Safety and Occupational Medicine, Nöldnerstrasse 40-42, D-10317 Berlin, Germany.ORCID 0000-0001-7827-8481
Universität Greifswald · DEFederal Institute for Occupational Safety and Health · DEMasaryk University · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cylindrospermopsin (CYN) is a cyanobacterial toxin that occurs in aquatic environments worldwide. It is known for its delayed effects in animals and humans such as inhibition of protein synthesis or genotoxicity. The molecular targets and the cell physiological mechanisms of CYN, however, are not well studied. As inhalation of CYN-containing aerosols has been identified as a relevant route of CYN uptake, we analyzed the effects of CYN on protein expression in cultures of immortalized human bronchial epithelial cells (16HBE14o

Indexed as

Cyanobacteria ToxinsEpithelial CellsAlkaloidsCell Cycle ProteinsHumansProteomicsAlkaloidsCell Cycle ProteinsCep55 protein, humanCyanobacteria Toxinscylindrospermopsinairway epithelial cellscell cyclecyanotoxincylindrospermopsincytokinesisextracellular matrixproteomics

Identifiers

PMID36422959
PMCPMC9698144
OpenAlexW4309210520

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.