Trial reportJournal of medical Internet research2022
Countering Antivax Misinformation via Social Media: Message-Testing Randomized Experiment for Human Papillomavirus Vaccination Uptake.
Trial report in Journal of medical Internet research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Strategies and prerequisites for combating health misinformation on social media: a systematic review.BMC public health · 2025Pooled it
- Social Media as an Effective Provider of Quality-Assured and Accurate Information to Increase Vaccine Rates: Systematic Review.Journal of medical Internet research · 2023Pooled it
- Digital Strategies To Counter Health Misinformation and Strengthen Vaccine Acceptance: a Scoping Review.Journal of community health · 2026Review
- Medication-Related Information on Social Media: Exploring Public Trust, Perceptions of Credibility, and Influence on Behavior.Health science reports · 2026Article
- Article
- Communication strategies in childhood vaccine hesitancy: a scoping review.Revista de saude publica · 2026Article
- Impacts of Sexual and Reproductive Health and Rights Misinformation in Digital Spaces on Human Rights Protection and Promotion: Scoping Review.JMIR infodemiology · 2025Article
- Coverage of HPV Vaccination and Influencing Factors Among Female College Students in Northern China.Vaccines · 2025Article
- The Role of Internet Information on Anti-HPV Vaccines: A Comprehensive Overview of a Double-Edged Sword.Vaccines · 2025Review
- Article
- Therapeutic Impact of GardasilViruses · 2025Article
- Birds of a feather? Mis- and dis-information on the social media platform X related to avian influenza.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2025Article
- Pediatric providers' views on participating in an HPV Vaccine Quality Improvement Intervention: a qualitative analysis.BMC pediatrics · 2024Article
- Communication inequalities and incomplete data hinder understanding of how social media affect vaccine uptake.BMJ (Clinical research ed.) · 2024Article
- Factors associated with HPV vaccine acceptability and hesitancy among Black mothers with young daughters in the United States.Frontiers in public health · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundSuboptimal adolescent human papillomavirus (HPV) vaccination rates have been attributed to parental perceptions of the HPV vaccine. The internet has been cited as a setting where misinformation and controversy about HPV vaccination have been amplified.
objectiveWe aimed to test message effectiveness in changing parents' attitudes and behavioral intentions toward HPV vaccination.
methodsWe conducted a web-based message-testing experiment with 6 control messages and 25 experimental messages and 5 from each of the 5 salient themes about HPV vaccination (theme 1: safety, side effects, risk, and ingredient concerns and long-term or major adverse events; theme 2: distrust of the health care system; theme 3: HPV vaccine effectiveness concerns; theme 4: connection to sexual activity; and theme 5: misinformation about HPV or HPV vaccine). Themes were identified from previous web-based focus group research with parents, and specific messages were developed by the study team using content from credible scientific sources. Through an iterative process of message development, the messages were crafted to be appropriate for presentation on a social media platform. Among the 1713 participants recruited via social media and crowdsourcing sites, 1043 eligible parents completed a pretest survey questionnaire. Participants were then randomly assigned to 1 of the 31 messages and asked to complete a posttest survey questionnaire that assessed attitudes toward the vaccine and perceived effectiveness of the viewed message. A subgroup of participants (189/995, 19%) with unvaccinated children aged 9 to 14 years was also assessed for their behavioral intention to vaccinate their children against HPV.
resultsParents in the experimental group had increased positive attitudes toward HPV vaccination compared with those in the control group (t
conclusionsEvidence-based messages directly countering misinformation and promoting HPV vaccination in social media environments can positively influence parents' attitudes and behavioral intentions to vaccinate their children against HPV.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.