Evidence map›Paper›PMID 36422848›Full record

ArticleBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]2023

Are γ-terpinene, 1,8-cineole, p-coumaric acid, and quercetin active against wild-type and non-wild-type Sporothrix brasiliensis to itraconazole?

Stefanie Bressan Waller, Márcia Kutscher Ripoll, Helena Piúma Gonçalves, Daiane Flores Dalla Lana, Renata Osório de Faria, Mário Carlos Araújo Meireles, Alexandre Meneghello Fuentefria, João Roberto Braga de Mello, Marlete Brum Cleff

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Stefanie Bressan WallerDepartamento de Veterinária Preventiva, Faculdade de Veterinária, Universidade Federal de Pelotas (UFPel), 1 Campus Universitário Capão Do Leão, Pelotas, RS, 96010-900, Brazil. waller.stefanie@yahoo.com.br.ORCID http://orcid.org/0000-0001-6719-1794
Márcia Kutscher RipollDepartamento de Veterinária Preventiva, Faculdade de Veterinária, Universidade Federal de Pelotas (UFPel), 1 Campus Universitário Capão Do Leão, Pelotas, RS, 96010-900, Brazil.
Helena Piúma GonçalvesDepartamento de Clínicas Veterinária, Faculdade de Veterinária, Universidade Federal de Pelotas (UFPel), Pelotas, RS, Brazil.
Daiane Flores Dalla LanaDepartamento de Análises, Faculdade de Farmácia, Universidade Federal Do Rio Grande Do Sul (UFRGS), Porto Alegre, RS, Brazil.
Renata Osório de FariaDepartamento de Veterinária Preventiva, Faculdade de Veterinária, Universidade Federal de Pelotas (UFPel), 1 Campus Universitário Capão Do Leão, Pelotas, RS, 96010-900, Brazil.
Mário Carlos Araújo MeirelesDepartamento de Veterinária Preventiva, Faculdade de Veterinária, Universidade Federal de Pelotas (UFPel), 1 Campus Universitário Capão Do Leão, Pelotas, RS, 96010-900, Brazil.
Alexandre Meneghello FuentefriaDepartamento de Análises, Faculdade de Farmácia, Universidade Federal Do Rio Grande Do Sul (UFRGS), Porto Alegre, RS, Brazil.
João Roberto Braga de MelloDepartamento de Farmacologia, Instituto de Ciências Básicas da Saúde, Universidade Federal Do Rio Grande Do Sul (UFRGS), Porto Alegre, RS, Brazil.
Marlete Brum CleffDepartamento de Clínicas Veterinária, Faculdade de Veterinária, Universidade Federal de Pelotas (UFPel), Pelotas, RS, Brazil.
Universidade Federal de Pelotas · BRUniversidade Federal do Rio Grande do Sul · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The emergence of itraconazole (ITZ)-resistant Sporothrix brasiliensis in feline and canine cases in southern Brazil has hampered the clinical cure of animal sporotrichosis, encouraging the search for therapeutic alternatives. The promising use of plants extracts from Lamiaceae family is known; however, there are no studies with its major compounds, as γ-terpinene (γTER), 1,8-cineole (1,8CIN), p-coumaric acid (pCOU), and quercetin (QUER). For the first time, we evaluated the antifungal, synergistic, cytotoxic activities and action mechanism of these compounds against S. brasiliensis. For this, 28 S. brasiliensis from cats (n = 24) and dogs (n = 4) and standard strains of S. brasiliensis and S. schenckii (n = 4) were tested by M38-A2 (CLSI), revealing non-wild-type (WT) isolates to ITZ on 54.2% (13/24) and 75% (03/04) of feline and canine isolates, respectively. Of the compounds, γTER stood out against all isolates (MIC/MFC 0.75 to > 3 mg/ml; MIC

Indexed as

SporothrixSporotrichosisAnimalsAntifungal AgentsCatsCoumaric AcidsCyclohexane MonoterpenesDogsEucalyptolItraconazoleMicrobial Sensitivity TestsQuercetinAntifungal AgentsCoumaric AcidsCyclohexane MonoterpenesEucalyptolgamma-terpineneItraconazolep-coumaric acidQuercetinAction mechanismAntifungalCytotoxicityPhenolic compoundsSporotrichosisSynergism

Identifiers

PMID36422848
PMCPMC9944583
OpenAlexW4309924926

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.