Evidence map›Paper›PMID 36422829›Full record

SynthesisJournal of endocrinological investigation2023

The physiological sonographic features of the ovary in healthy subjects: a joint systematic review and meta-analysis by the Italian Society of Gynecology and Obstetrics (SIGO) and the Italian Society of Endocrinology (SIE).

F Moro, I Scavello, E Maseroli, G Rastrelli, C Baima Poma, C Bonin, F Dassie, S Federici, S Fiengo, L Guccione and 10 more

Open access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of endocrinological investigation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2024
    Review
  6. Diagnosis and management of polycystic ovarian syndrome.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 13 institutions in 1 country.

F Moro *Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy.
I Scavello *Department of Experimental Clinical and Biomedical Sciences "Mario Serio", University of Florence, Viale Pieraccini 6, 50134, Florence, Italy.
E MaseroliAndrology, Women's Endocrinology and Gender Incongruence Unit, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
G RastrelliDepartment of Experimental Clinical and Biomedical Sciences "Mario Serio", University of Florence, Viale Pieraccini 6, 50134, Florence, Italy.
C Baima PomaConsultorio Familiare ASL Città di Torino, Turin, Italy.
C BoninUnit of Obstetrics and Gynecology B, Department of Women and Children's Health, AOUI Verona, Verona, Italy.
F DassieDepartment of Medicine, Clinica Medica 3-Azienda Ospedaliera, University of Padua, Padua, Italy.
S FedericiUnit of Andrology and Reproductive Endocrinology, Department of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, 20149, Milan, Italy.
S FiengoDepartment of Obstetrics and Gynaecology, ARNAS Civico Hospital, Palermo, Italy.
L GuccioneDepartment of Systems' Medicine, University of Tor Vergata, Rome, Italy.
M VillaniUnit of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Verona, Verona, Italy.
A GambineriDivision of Endocrinology and Diabetes Prevention and Care, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
R MioniDepartment of Medicine, Clinica Medica 3-Azienda Ospedaliera, University of Padua, Padua, Italy.
P MoghettiUnit of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Verona, Verona, Italy.
C MorettiDepartment of Systems' Medicine, University of Tor Vergata, Rome, Italy.
L PersaniUnit of Andrology and Reproductive Endocrinology, Department of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, 20149, Milan, Italy.
G ScambiaIstituto Di Clinica Ostetrica E Ginecologica, Università Cattolica del Sacro Cuore, Rome, Italy.
F GiorginoSection of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, Bari, Italy.
L VignozziDepartment of Experimental Clinical and Biomedical Sciences "Mario Serio", University of Florence, Viale Pieraccini 6, 50134, Florence, Italy. linda.vignozzi@unifi.it.ORCID http://orcid.org/0000-0003-0907-0630
Women’s Endocrinology Group of the Italian Society of Endocrinology
Azienda Ospedaliero-Universitaria Careggi · ITUniversity of Rome Tor Vergata · ITUniversity of Padua · ITUniversity of Verona · ITAzienda USL di Bologna · ITUniversity of Milan · ITAgostino Gemelli University Polyclinic · ITAzienda di Rilievo Nazionale ed Alta Specializzazione · ITAzienda Ospedaliera Universitaria Integrata Verona · ITIRCCS Istituto Auxologico Italiano · ITUniversità Cattolica del Sacro Cuore · ITUniversity of Bari Aldo Moro · ITUniversity of Florence · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThere is a lack of uniformity in the definition of normal ovary ultrasound parameters. Our aim was to summarize and meta-analyze the evidence on the topic. Full-text English articles published through December 31, 2020 were retrieved via MEDLINE and Embase. Data available for meta-analysis included: ovarian follicular count, ovarian volume, and ovarian Pulsatility Index (PI) assessed by Doppler ultrasound.

methodsCohort, cross-sectional, prospective studies with a single or double arm were considered eligible. Interventional studies were included when providing baseline data. Both studies on pre- and post-menopausal women were screened; however, data on menopausal women were not sufficient to perform a meta-analysis. Studies on pre-pubertal girls were considered separately. Eighty-one papers were included in the meta-analysis.

resultsThe mean ovarian volume was 6.11 [5.81-6.42] ml in healthy women in reproductive age (5.81-6.42) and 1.67 ml [1.02-2.32] in pre-pubertal girls. In reproductive age, the mean follicular count was 8.04 [7.26-8.82] when calculated in the whole ovary and 5.88 [5.20-6.56] in an ovarian section, and the mean ovarian PI was 1.86 [1.35-2.37]. Age and the frequency of the transducers partly modulated these values. In particular, the 25-30-year group showed the higher mean follicular count (9.27 [7.71-10.82]), followed by a progressive age-related reduction (5.67 [2.23-9.12] in fertile women > 35 years). A significant difference in follicular count was also found according to the transducer's upper MHz limit.

conclusionOur findings provide a significant input to improve the interpretation and diagnostic accuracy of ovarian ultrasound parameters in different physiological and pathological settings.

Indexed as

GynecologyOvaryAdultCross-Sectional StudiesFemaleHealthy VolunteersHumansPregnancyProspective StudiesFollicular countOvarian volumeOvaryUltrasound

Identifiers

PMID36422829
PMCPMC9938076
OpenAlexW4309889714

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.