Evidence map›Paper›PMID 36422814›Full record

ArticleMolecular neurobiology2023

The Identification of Human Translational Biomarkers of Neuropathic Pain and Cross-Species Validation Using an Animal Model.

Bethan Young, John Stephenson, Barira Islam, Nikita N Burke, Elaine M Jennings, David P Finn, Patrick C McHugh

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Bethan YoungCentre for Biomarker Research, University of Huddersfield, Huddersfield, HD1 3DH, UK.
John StephensonCentre for Biomarker Research, University of Huddersfield, Huddersfield, HD1 3DH, UK.
Barira IslamCentre for Biomarker Research, University of Huddersfield, Huddersfield, HD1 3DH, UK.
Nikita N BurkeSchool of Nursing and Midwifery, University of Galway, Galway, Ireland.
Elaine M JenningsCentre for Pain Research, University of Galway, Galway, Ireland.
David P FinnCentre for Pain Research, University of Galway, Galway, Ireland.
Patrick C McHughCentre for Biomarker Research, University of Huddersfield, Huddersfield, HD1 3DH, UK. p.c.mchugh@hud.ac.uk.ORCID http://orcid.org/0000-0003-0661-919X
University of Huddersfield · GBOllscoil na Gaillimhe – University of Galway · IEUniversity Hospital Galway · IE

Funding

British Pain Society Lulow AwardCentre for Biomarker Research, University of Huddersfield Doctoral trainingPain Relief Foundation Small grant - McHughScience Foundation Ireland 10/IN.1/B2976
6 · The paper itself

Abstract

Neuropathic pain is a common chronic condition, which remains poorly understood. Many patients receiving treatment continue to experience severe pain, due to limited diagnostic/treatment management programmes. The development of objective clinical diagnostic/treatment strategies requires identification of robust biomarkers of neuropathic pain. To this end, we looked to identify biomarkers of chronic neuropathic pain by assessing gene expression profiles in an animal model of neuropathic pain, and differential gene expression in patients to determine the potential translatability. We demonstrated cross-species validation of several genes including those identified through bioinformatic analysis by assessing their expression in blood samples from neuropathic pain patients, according to conservative assessments of significance measured using Bonferroni-corrected p-values. These include CASP5 (p = 0.00226), CASP8 (p = 0.00587), CASP9 (p = 2.09 × 10

Indexed as

NeuralgiaAdaptor Proteins, Signal TransducingAnimalsBiomarkersChronic DiseaseHumansMembrane ProteinsMitochondrial ProteinsModels, AnimalPain MeasurementProteinsAdaptor Proteins, Signal TransducingBiomarkersMembrane ProteinsMitochondrial ProteinsPLAC8 protein, humanProteinsROMO1 protein, humanSH3BGRL3 protein, humanTMEM88 protein, humanAUROC analysisBiomarkerCASP9Chronic neuropathic painDorsal hornSNL

Identifiers

PMID36422814
PMCPMC9899164
OpenAlexW4309923833

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.