Evidence map›Paper›PMID 36422669›Full record

ArticleJournal of neurology2023

Multidomain cognitive impairment in non-hospitalized patients with the post-COVID-19 syndrome: results from a prospective monocentric cohort.

Ann-Katrin Schild, Yasemin Goereci, Daniel Scharfenberg, Kim Klein, Joachim Lülling, Dix Meiberth, Finja Schweitzer, Sophie Stürmer, Philip Zeyen, Derya Sahin and 7 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
6.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 2 countries.

Ann-Katrin Schild *Department of Psychiatry, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany. ann-katrin.schild@uk-koeln.de.ORCID http://orcid.org/0000-0002-1920-0198
Yasemin Goereci *Department of Neurology, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID http://orcid.org/0000-0003-3330-8231
Daniel ScharfenbergDepartment of Psychiatry, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Kim KleinDepartment of Psychiatry, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Joachim LüllingDepartment of Psychiatry, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Dix MeiberthDepartment of Psychiatry, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Finja SchweitzerDepartment of Neurology, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Sophie StürmerDepartment of Psychiatry, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Philip ZeyenDepartment of Psychiatry, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Derya SahinDepartment of Psychiatry, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Gereon R FinkDepartment of Neurology, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Frank JessenDepartment of Psychiatry, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Christiana FrankeDepartment of Neurology with Experimental Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Oezguer A OnurDepartment of Neurology, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Josef KesslerDepartment of Neurology, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Clemens Warnke *Department of Neurology, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
Franziska Maier *Department of Psychiatry, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany.
University of Cologne · DEForschungszentrum Jülich · DEHumboldt-Universität zu Berlin · DE

Funding

Deutsche Forschungsgemeinschaft PR 1274/8-1
6 · The paper itself

Abstract

backgroundA fraction of patients with asymptomatic to mild/moderate acute COVID-19 disease report cognitive deficits as part of the post-COVID-19 syndrome. This study aimed to assess the neuropsychological profile of these patients.

methodsAssessment at baseline (three months or more following acute COVID-19) of a monocentric prospective cohort of patients with post-COVID-19 syndrome. Multidomain neuropsychological tests were performed, and questionnaires on depression, anxiety, fatigue, sleep, and general health status were administered.

resultsOf the 58 patients screened, six were excluded due to possible alternative causes of cognitive impairment (major depression, neurodegenerative disease). Of the remaining 52 individuals, only one had a below-threshold screening result on Mini-Mental State Examination, and 13 scored below the cut-off on Montreal Cognitive Assessment. Extended neuropsychological testing revealed a neurocognitive disorder (NCD) in 31 (59.6%) participants with minor NCD in the majority of cases (n = 26). In patients with NCD, the cognitive domains learning/memory and executive functions were impaired in 60.7%, complex attention in 51.6%, language in 35.5%, and perceptual-motor function in 29.0%. Cognitive profiles were associated with daytime sleepiness but not with depression, anxiety, sleep quality, total general health status, or fatigue.

conclusionNeurocognitive impairment can be confirmed in around 60% of individuals with self-reported deficits as part of post-COVID-19 syndrome following a mild acute COVID-19 disease course. Notably, screening tests cannot reliably detect this dysfunction. Standard psychiatric assessments showed no association with cognitive profiles. Longitudinal studies are needed to further evaluate the course of neurocognitive deficits and clarify pathophysiology.

Indexed as

Cognitive DysfunctionCOVID-19Neurodegenerative DiseasesFatigueHumansNeuropsychological TestsPost-Acute COVID-19 SyndromeProspective StudiesCognitive deficitsNeurocognitive disorderNeuropsychologyPost-COVID-19 syndromeSARS-CoV-2Subjective deficits

Identifiers

PMID36422669
PMCPMC9686246
OpenAlexW4309891401

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.