Evidence map›Paper›PMID 36422544›Full record

ArticlePharmaceuticals (Basel, Switzerland)2022

Copaiba Oil Resin Exerts an Additive Effect to Babassu Oil on Behavioral Changes in Human Endometriotic Cell Cultures.

Julianna Henriques da Silva, Leticia Coli Louvisse de Abreu, Renato Ferrari, Celia Yelimar Palmero Quintana, Eliane Gouvêa de Oliveira Barros, Natália de Moraes Cordeiro, Bruno Pontes, Valeria Pereira de Sousa, Lucio Mendes Cabral, Patricia Dias Fernandes and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Special Issue "Ethnopharmacology in Latin America".Pharmaceuticals (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Julianna Henriques da SilvaUniversidade Federal do Rio de Janeiro, Instituto de Ciências Biomédicas, Programa de Pesquisa em Biologia Celular e do Desenvolvimento, Rio de Janeiro 21.941-902, Brazil.
Leticia Coli Louvisse de AbreuUniversidade Federal do Rio de Janeiro, Faculdade de Farmácia, Laboratório de Tecnologia Farmacêutica, Rio de Janeiro 21.941-902, Brazil.
Renato FerrariUniversidade Federal do Rio de Janeiro, Hospital Universitário Moncorvo Filho, Instituto de Ginecologia, Rio de Janeiro 20.211-340, Brazil.
Celia Yelimar Palmero QuintanaUniversidade Federal do Rio de Janeiro, Instituto de Ciências Biomédicas, Programa de Pesquisa em Biologia Celular e do Desenvolvimento, Rio de Janeiro 21.941-902, Brazil.
Eliane Gouvêa de Oliveira BarrosUniversidade Federal do Rio de Janeiro, Instituto de Ciências Biomédicas, Programa de Pesquisa em Biologia Celular e do Desenvolvimento, Rio de Janeiro 21.941-902, Brazil.ORCID 0000-0002-0020-6653
Natália de Moraes CordeiroUniversidade Federal do Rio de Janeiro, Instituto de Ciências Biomédicas, Programa de Pesquisa em Descoberta de Fármacos, Laboratório de Farmacologia dor e da Inflamação, Rio de Janeiro 21.941-90, Brazil.
Bruno PontesUniversidade Federal do Rio de Janeiro, Instituto de Ciências Biomédicas, Programa de Pesquisa em Biologia Celular e do Desenvolvimento, Rio de Janeiro 21.941-902, Brazil.ORCID 0000-0002-0831-1204
Valeria Pereira de SousaUniversidade Federal do Rio de Janeiro, Faculdade de Farmácia, Laboratório de Tecnologia Farmacêutica, Rio de Janeiro 21.941-902, Brazil.
Lucio Mendes CabralUniversidade Federal do Rio de Janeiro, Faculdade de Farmácia, Laboratório de Tecnologia Farmacêutica, Rio de Janeiro 21.941-902, Brazil.
Patricia Dias FernandesUniversidade Federal do Rio de Janeiro, Instituto de Ciências Biomédicas, Programa de Pesquisa em Descoberta de Fármacos, Laboratório de Farmacologia dor e da Inflamação, Rio de Janeiro 21.941-90, Brazil.ORCID 0000-0001-6870-6745
Luiz Eurico NasciuttiUniversidade Federal do Rio de Janeiro, Instituto de Ciências Biomédicas, Programa de Pesquisa em Biologia Celular e do Desenvolvimento, Rio de Janeiro 21.941-902, Brazil.
Universidade Federal do Rio de Janeiro · BR

Funding

Conselho Nacional de Pesquisa (CNPq) 304394/2017-3; 308557/2021-2Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/202.763/2018; SEI-260003/001182/2020-auxílio; E-26/010.001837/2015; SEI-260003/003464/2022
6 · The paper itself

Abstract

backgroundCurrent drugs for the treatment of endometriosis are not able to completely cure the condition, and significant side effects hinder the continuation of treatment. Therefore, it is necessary to search for new drug candidates. In the present paper, the use of plant extracts is highlighted. Babassu oil and Copaiba oil resin have several therapeutic properties. We investigated the in vitro effects of two nanoemulsions containing oil extracted from Babassu (

methodsCESC, EuESC, and EctESC were taken and treated with SNEDDS-18 and SNEDDS-18/COPA to evaluate their effects on cytotoxicity, cell morphology, proliferation, and signaling pathways.

resultsAfter 48 h of incubation with SNEDDS-18 and SNEDDS-18/COPA, cell viability and proliferation were inhibited, especially in EctESC. The lowest concentration of both nanoemulsions reduced cell viability and proliferation and broke down the cytoskeleton in EctESCs. After 24 h of treatment a decrease in IL-1, TNF-α, and MCP-1 was observed, as well as an increase in IL-10 production.

conclusionsBoth nanoemulsions can affect endometriotic stromal cell behaviors, thus revealing two potential candidates for new phytotherapeutic agents for the management of endometriosis.

Indexed as

Copaifera lansgdorffii nanoemulsionendometriosisOrbignya speciosaself-nanoemulsifying drug delivery system

Identifiers

PMID36422544
PMCPMC9695379
OpenAlexW4309315285

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.