Observational studyTurkish journal of medical sciences2022
Identification of sepsis-associated encephalopathy risk factors in elderly patients: a retrospective observational cohort study.
Observational study in Turkish journal of medical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Factors contributing to sepsis-associated encephalopathy: a comprehensive systematic review and meta-analysis.Frontiers in medicine · 2024Pooled it
- Ulinastatin Treatment Associated with Lower Sepsis-Associated Encephalopathy Risk in Sepsis Patients: A Multicenter Observational Study.Shock (Augusta, Ga.) · 2026Observational
- Construction and validation of a predictive nomogram for 28-day mortality in critically ill patients with toxic encephalopathy.BMC medical informatics and decision making · 2026Article
- SNHG5 Exacerbates Sepsis-Induced Inflammatory Injury in Coronary Artery Endothelial Cells by Regulating METAP2-Mediated IL-8 Secretion.Mediators of inflammation · 2026Article
- Online Clinical Calculator for Predicting 28-Day Mortality in Older Adult Patients With Sepsis-Associated Encephalopathy: Retrospective Study Using MIMIC-IV.JMIR medical informatics · 2025Article
- Prevalence, symptoms, risk factors and impact of sepsis-associated encephalopathy in emergency department patients: a case-control study.BMC emergency medicine · 2025Article
- An approach for the emergency diagnosis and treatment of sepsis-associated encephalopathy in elderly individuals: a literature review.World journal of emergency medicine · 2025Review
- The Role of Ultrasonographic Assessment of Optic Nerve Sheath Diameter in Prediction of Sepsis-Associated Encephalopathy: Prospective Observational Study.Neurocritical care · 2025Observational
- Association of serum Netrin-1, NSE, and S100β with brain injury severity and prognosis in patients with sepsis-associated encephalopathy.Biomolecules & biomedicine · 2025Article
- The frequency of sepsis-associated delirium in intensive care unit and its effect on nurse workload.Journal of clinical nursing · 2025Article
- Microbiological and clinical predictors of sepsis-associated encephalopathy in bloodstream infections: a retrospective cohort study.Frontiers in cellular and infection microbiology · 2025Article
- The impact of sedation and analgesia scores on prognosis in critically ill sepsis patients with sepsis-associated encephalopathy: a retrospective analysis.Frontiers in neurology · 2025Article
- Development and Validation of a Dynamic Nomogram for Sepsis-Associated Encephalopathy in Elderly ICU Patients with Sepsis: A Retrospective Cohort Study.International journal of general medicine · 2025Article
- Comprehensive risk factor-based nomogram for predicting one-year mortality in patients with sepsis-associated encephalopathy.Scientific reports · 2024Article
- Clinical image of sepsis-associated encephalopathy midstHeliyon · 2024Article
- Development and validation of a nomogram to predict the risk of sepsis-associated encephalopathy for septic patients in PICU: a multicenter retrospective cohort study.Journal of intensive care · 2024Article
- Improved prediction of sepsis-associated encephalopathy in intensive care unit sepsis patients with an innovative nomogram tool.Frontiers in neurology · 2024Article
- The spectrum of sepsis-associated encephalopathy: a clinical perspective.Critical care (London, England) · 2023Review
- High Mobility Group Box 1 (HMGB1): Potential Target in Sepsis-Associated Encephalopathy.Cells · 2023Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSepsis-associated encephalopathy (SAE) is a severe complication of sepsis that affects upwards of half of all sepsis patients. Few studies have examined the etiology and risk factors of SAE among elderly patients. This study was designed to explore the epidemiology of SAE and the risk factors associated with its development in elderly populations.
methodsThis was a retrospective analysis of elderly sepsis patients admitted to our intensive care unit between January 2017 and January 2022. We then compared non-SAE and SAE groups concerning baseline clinicopathological findings, underlying diseases, infection site, disease type, disease severity, biochemical findings, and 28-day mortality. We further stratified patients in the SAE group based on whether or not they survived for 28 days, and we compared the above data between these groups.
resultsOf the 222 elderly sepsis patients, 132 (59.46%) had SAE. SAE patients were found to be significantly older than non-SAE patients. Both age and blood sodium concentrations were found to be associated with SAE risk, while elderly sepsis patients without underlying chronic obstructive pulmonary disease (COPD) have a relatively higher risk of developing SAE. The SAE group also had a significantly higher rate of 28-day mortality, and sequential organ failure assessment (SOFA) scores were a risk factor associated with 28-day mortality. DISCUSSION: Among elderly sepsis patients, SAE risk increases with advancing age, higher blood sodium concentrations, and without underlying COPD. SAE incidence is associated with a poorer prognosis, and SOFA scores are independent predictors of increased mortality among elderly SAE patients.
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