Evidence map›Paper›PMID 36422330›Full record

ArticleMicroorganisms2022

The Marine Compound Tartrolon E Targets the Asexual and Early Sexual Stages of

Alexis Cotto-Rosario, Emma Y D Miller, Fernanda G Fumuso, Jason A Clement, Matthew J Todd, Roberta M O'Connor

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microorganisms, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Tartrolon E rapidly blocks Toxoplasma gondii capacity to invade host cells.International journal for parasitology. Drugs and drug resistance · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Alexis Cotto-RosarioDepartment of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164, USA.ORCID 0000-0003-0335-2207
Emma Y D MillerDepartment of Veterinary and Biomedical Sciences, University of Minnesota, St. Paul, MN 55108, USA.
Fernanda G FumusoDepartment of Veterinary and Biomedical Sciences, University of Minnesota, St. Paul, MN 55108, USA.ORCID 0000-0002-4561-9005
Jason A ClementBaruch S. Blumberg Institute, Doylestown, PA 18902, USA.
Matthew J ToddBaruch S. Blumberg Institute, Doylestown, PA 18902, USA.
Roberta M O'ConnorDepartment of Veterinary and Biomedical Sciences, University of Minnesota, St. Paul, MN 55108, USA.ORCID 0000-0003-2757-754X
University of Minnesota · USBaruch S. Blumberg Institute · USWashington State University · US

Funding

Development of a new marine natural product for the treatment of cryptosporidiosis, an AIDS-defining diseaseR01AI154943 · NIAID · WASHINGTON STATE UNIVERSITY · PI O'CONNOR, ROBERTA M · 2020 to 2024
$2.0M
NIAID NIH HHS R01 AI154943NIH HHS R01AI154943
6 · The paper itself

Abstract

New therapeutic agents for cryptosporidiosis are a critical medical need. The marine organic compound, tartrolon E (trtE), is highly effective against multiple apicomplexan parasites, including

Indexed as

antiparasitic compoundcryptosporidiosisCryptosporidiumdrug candidateslife cycle stagesmarine natural productsphenotypic assays

Identifiers

PMID36422330
PMCPMC9693555
OpenAlexW4309032771

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.