ArticleMicroorganisms2022
Immunostimulatory Activity of Lactic Acid Bacteria Cell-Free Supernatants through the Activation of NF-κB and MAPK Signaling Pathways in RAW 264.7 Cells.
Article in Microorganisms, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 40 citations in OpenAlex.
- Comprehensive Evaluation of Safety, Functional Properties, and Immunomodulatory Activity of 19 Probiotic Strains Approved by the Ministry of Food and Drug Safety (MFDS).Journal of microbiology and biotechnology · 2026Article
- Immune-Enhancing Effects of IBP35, a Combination ofFood science & nutrition · 2026Article
- Lactose-Free Fermented Milk Production UsingJournal of microbiology and biotechnology · 2026Article
- Evaluation of the immunomodulatory properties ofOpen veterinary journal · 2025Article
- Review
- Immunomodulatory Properties and Ameliorative Effects ofJournal of microbiology and biotechnology · 2025Article
- Exploring the potential effects ofNarra J · 2025Article
- Concurrent Hydrolysis-Fermentation ofFoods (Basel, Switzerland) · 2025Article
- The Immune-Enhancing Effects of aCurrent issues in molecular biology · 2025Article
- Inhibitory effect of cell-free supernatants ofVeterinary research forum : an international quarterly journal · 2025Article
- PasteurizedFrontiers in microbiology · 2025Article
- Article
- Probiotic Characteristics and the Anti-Inflammatory Effects ofMicroorganisms · 2024Article
- In Vitro Evaluation of Probiotic Properties and Anti-Pathogenic Effects ofFoods (Basel, Switzerland) · 2024Article
- Immunostimulatory Effect of Ovomucin Hydrolysates by Pancreatin in RAW 264.7 Macrophages via Mitogen-Activated Protein Kinase (MAPK) Signaling Pathway.Food science of animal resources · 2024Article
- Immunomodulatory Activity on Human Macrophages by Cell-Free Supernatants to Explore the Probiotic and Postbiotic Potential of Lactiplantibacillus plantarum Strains of Plant Origin.Probiotics and antimicrobial proteins · 2024Article
- Evaluation of immunomodulatory potential of probiotic conditioned medium on murine macrophages.Scientific reports · 2024Article
- Heat-Treated ParaprobioticJournal of microbiology and biotechnology · 2024Article
- Gamma Amino Butyric Acid (GABA) and Ferulic Acid Esterase (FAE) Producing Psychobiotic Bacteria Isolated from Cereal-Based Fermented Food.Current microbiology · 2024Article
- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lactic acid bacteria (LAB) can improve host health and has strong potential for use as a health functional food. Specific strains of LAB have been reported to exert immunostimulatory effects. The primary goal of this study was to evaluate the immunostimulatory activities of novel LAB strains isolated from humans and foods and to investigate the probiotic properties of these strains. Cell-free supernatants (CFS) obtained from selected LAB strains significantly increased phagocytosis and level of nitric oxide (NO) and pro-inflammatory cytokines such as tumor necrosis factor (TNF)-α and interleukin (IL)-6 in RAW264.7 macrophage cells. The protein expression of inducible NO synthase (iNOS) and cyclooxygenase (COX)-2, which are immunomodulators, was also upregulated by CFS treatment. CFS markedly induced the phosphorylation of nuclear factor-κB (NF-κB) and MAPKs (ERK, JNK, and p38). In addition, the safety of the LAB strains used in this study was demonstrated by hemolysis and antibiotic resistance tests. Their stability was confirmed under simulated gastrointestinal conditions. Taken together, these results indicate that the LAB strains selected in this study could be useful as probiotic candidates with immune-stimulating activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.