Exposure to Environmentally Relevant Levels of PFAS Causes Metabolic Changes in the Freshwater Amphipod

Georgia M Sinclair, Sara M Long, Navneet Singh, Timothy L Coggan, Matthew P J Askeland, Oliver A H Jones

Abstract read

In one paragraph

Article in Metabolites, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Georgia M SinclairAustralian Centre for Research on Separation Science (ACROSS), School of Science, RMIT University, Bundoora West Campus, P.O. Box 71, Bundoora, VIC 3083, Australia.ORCID 0000-0003-1119-5897

Sara M LongAquatic Environmental Stress Research Group (AQUEST), School of Science, RMIT University, Bundoora West Campus, P.O. Box 71, Bundoora, VIC 3083, Australia.ORCID 0000-0001-5323-8846

Navneet SinghADE Consulting Group, Williamstown North, VIC 3016, Australia.

Timothy L CogganADE Consulting Group, Williamstown North, VIC 3016, Australia.

Matthew P J AskelandADE Consulting Group, Williamstown North, VIC 3016, Australia.

Oliver A H JonesAustralian Centre for Research on Separation Science (ACROSS), School of Science, RMIT University, Bundoora West Campus, P.O. Box 71, Bundoora, VIC 3083, Australia.ORCID 0000-0002-4541-662X

Funding

Australian Government Research Training Program (RTP) Scholarship RMIT Research Stipend(RRSS-SC)

6 · The paper itself

Abstract

Per and polyfluoroalkyl substances (PFAS) are of concern to environmental regulators due to their widespread occurrence, persistence and reported toxicity. However, little data exist on the effects of PFAS at environmentally relevant concentrations. The development of molecular markers for PFAS exposure would therefore be useful to better understand the environmental risks of these compounds. In this study, we assessed if such markers could be developed using Gas Chromatography-Mass Spectrometry-based metabolomics. We exposed the freshwater amphipod

Indexed as

amphipodsbioconcentrationenvironmentGas Chromatographymetabolomicsmonitoringregulationtoxicologywater quality

Identifiers

PMID36422275

DOI10.3390/metabo12111135

PMCPMC9698423

What OpenQuestion holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.