ArticleJournal of personalized medicine2022
Prolonged Maternal Separation Reduces Anxiety State and Increases Compulsive Burying Activity in the Offspring of BALB/c Mice.
Article in Journal of personalized medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Impaired Neuregulin 1 Processing is Associated with Synaptic and Behavioral Abnormalities in a Prenatal Valproic Acid Model of Autism.International journal of biological sciences · 2026Article
- Isorhamnetin Alleviates Early-Life Stress-Induced Anxiety and Depression in Male Mice: Neuroinflammatory Modulation and Sirt1/NF-κB Signaling Insights.Molecular neurobiology · 2025Article
- Methods for Modeling Early Life Stress in Rodents.Methods in molecular biology (Clifton, N.J.) · 2025Review
- Effects of Early Stress Exposure on Anxiety-like Behavior andBiomolecules · 2024Article
- Comparing the effects of infant maternal and sibling separation on adolescent behavior in rats (Rattus norvegicus).PloS one · 2024Article
- N-Acetylcysteine Alleviates Depressive-Like Behaviors in Adolescent EAAC1International journal of biological sciences · 2024Article
- Maternal separation and its developmental consequences on anxiety and parvalbumin interneurons in the amygdala.Journal of neural transmission (Vienna, Austria : 1996) · 2023Article
- Communal nesting differentially attenuates the impact of pre-weaning social isolation on behavior in male and female rats during adolescence and adulthood.Frontiers in behavioral neuroscience · 2023Article
- The impact of environmental factors during maternal separation on the behaviors of adolescent C57BL/6 mice.Frontiers in molecular neuroscience · 2023Article
- Resveratrol ameliorates maternal separation-induced anxiety- and depression-like behaviors and reduces Sirt1-NF-kB signaling-mediated neuroinflammation.Frontiers in behavioral neuroscience · 2023Article
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Authors and funding
8 authors at 5 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe elevated plus maze (EPM) and the marble burying (MB) tests are common behavioral tests used for behavioral phenotyping in mouse models for neurodevelopmental disorders. However, the behavioral effects of maternal separation (MS), a standard paradigm for early life stress in animals, in both the EPM and MB tests remain incompletely known.
objectivesThis study aimed to investigate the behavioral effects of prolonged MS in the offspring of mice using the EPM and MB tests.
methodsMale BALB/c mice were isolated from their mothers for 4 h each day during the first 30 days after birth. On day 50 postnatal, groups of separated and non-separated mice (
resultsThe findings of the EPM test revealed that separated mice exhibited anxiolytic-like behaviors, as evidenced by a significant increase in the latency to closed arms and the time spent in the open arms compared with non-separated mice. Separated mice also showed compulsive burying activity in the MB test, as determined by a significant increase in the number of buried marbles. The results of the actophotometer test did not show any significant change in locomotor activity.
conclusionsProlonged MS caused the adult offspring of mice to exhibit a decrease in anxiety state and increased compulsive burying activity, which were not associated with a change in locomotor activity. Further investigations with validated tests are needed to support these findings.
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