ArticleMarine drugs2022
Preparation and Hepatoprotective Activities of Peptides Derived from Mussels (
Article in Marine drugs, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Mytilus edulis-mediated green synthesis of selenium nanoparticles with antimicrobial and molluscicidal applications.Scientific reports · 2026Article
- Antioxidant dipeptide Threonyltyrosine from Porphyridium cruentum: in silico prediction and in vitro protection against paraquat-induced HaCaT cell damage.BMC chemistry · 2026Article
- Comparative peptidomic profile and bioactivities of Pacific oyster, Mytilus edulis, Argopecten irradians, Meretrix meretrix L. after simulated gastrointestinal digestion.European journal of nutrition · 2026Article
- Bioactive nanoparticles from clam extracts mitigate alcoholic liver injury by modulating multiple pathways.NPJ science of food · 2026Article
- Comparison of Alcohol-Induced Hepatoprotective Effects of the High Fischer Ratio Oligopeptides with/Without Half Substitution byFoods (Basel, Switzerland) · 2025Article
- Antitumor Activity ofMarine drugs · 2025Article
- Isolation and Purification of Novel Antioxidant Peptides from Mussel (Marine drugs · 2025Article
- Immunoenhancement Function of the Novel Hexapeptide (LVVLGH) from Thick-Shelled Mussel (Foods (Basel, Switzerland) · 2025Article
- Evaluation of Anticancer and Immunomodulatory Effects of Microwave-Extracted Polysaccharide fromFoods (Basel, Switzerland) · 2024Article
- Anti-Inflammatory Activity of Peptides fromFoods (Basel, Switzerland) · 2024Article
- Immune Enhancement of Clam Peptides on Immunosuppressed Mice Induced by Hydrocortisone.Molecules (Basel, Switzerland) · 2023Article
- Molecular and biotechnological characteristics of proteolytic activity fromAIMS microbiology · 2023Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Low molecular weight (<5 kDa) peptides from mussels (Mytilus edulis) (MPs) and the peptides from clams (Ruditapes philippinarum) (CPs) were prepared through enzymatic hydrolysis by proteases (dispase, pepsin, trypsin, alcalase and papain). Both the MPs and the CPs showed excellent in vitro scavenging ability of free radicals including OH, DPPH and ABTS in the concentration range of 0.625−10.000 mg/mL. By contrast, the MPs hydrolyzed by alcalase (MPs-A) and the CPs hydrolyzed by dispase (CPs-D) had the highest antioxidant activities. Furthermore, MPs-A and CPs-D exhibited protective capabilities against oxidative damage induced by H2O2 in HepG2 cells in the concentration range of 25−800 μg/mL. Meanwhile, compared with the corresponding indicators of the negative control (alcohol-fed) mice, lower contents of hepatic MDA and serums ALT and AST, as well as higher activities of hepatic SOD and GSH-PX were observed in experiment mice treated with MPs-A and CPs-D. The present results clearly indicated that Mytilus edulis and Ruditapes philippinarum are good sources of hepatoprotective peptides.
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Registered trials
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