Evidence map›Paper›PMID 36421875›Full record

ArticleBrain sciences2022

Association between Genetically Proxied Inhibition of HMG-CoA Reductase and Age at Onset of Huntington's Disease.

Yahui Zhu, Mao Li, Hongfen Wang, Fei Yang, Jiao Wang, Xusheng Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yahui ZhuMedical School of Chinese PLA, Beijing 100853, China.
Mao LiMedical School of Chinese PLA, Beijing 100853, China.
Hongfen WangMedical School of Chinese PLA, Beijing 100853, China.
Fei YangMedical School of Chinese PLA, Beijing 100853, China.
Jiao WangMedical School of Chinese PLA, Beijing 100853, China.
Xusheng HuangMedical School of Chinese PLA, Beijing 100853, China.ORCID 0000-0002-2451-0254

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious studies have found that statins may play a potential role in the age at onset (AAO) of Huntington's disease (HD). We performed this Mendelian randomization (MR) study to assess the association between genetically proxied inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and low-density lipoprotein (LDL) cholesterol with age at onset of HD.

methodsSingle-nucleotide polymorphisms (SNPs) in HMG-CoA reductase associated with LDL cholesterol in a genome-wide association study (GWAS) analysis were used. The summary data of residual AAO of HD were obtained from a GWAS meta-analysis (

resultsGenetically proxied plasma LDL cholesterol (β = 0.039, 95% CI = -0.454 to 0.531) and HMG-CoA reductase inhibition equivalent to a 1 mmol/L (38.7 mg/dL) reduction in LDL cholesterol (β = -2.228, 95% CI = -4.830 to 0.374) were not associated with age at onset of HD.

conclusionThe plasma LDL cholesterol levels and the reduction of plasma LDL cholesterol levels by the inhibition of HMG-CoA reductase (i.e., statins) were not associated with the age of HD onset.

Indexed as

HMG-CoA reductase inhibitionHuntington’s diseaseLDL cholesterolMendelian randomizationstatins

Identifiers

PMID36421875
PMCPMC9688104

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