Evidence map›Paper›PMID 36421850›Full record

ArticleGenes2022

Prevalence and Genotype-Phenotype Correlation of Lynch Syndrome in a Selected High-Risk Cohort from Qatar's Population.

Mariem Sidenna, Houssein Khodjet-El-Khil, Hajar Al Mulla, Mashael Al-Shafai, Hind Hassan Habish, Reem Al-Sulaiman, Salha Bujassoum Al-Bader

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Mariem SidennaDepartment of Adult and Pediatric Medical Genetics, Hamad Medical Corporation, Doha 3050, Qatar.
Houssein Khodjet-El-KhilDepartment of Biomedical Science, College of Health Sciences, QU Health, Qatar University, Doha 2713, Qatar.
Hajar Al MullaDepartment of Adult and Pediatric Medical Genetics, Hamad Medical Corporation, Doha 3050, Qatar.
Mashael Al-ShafaiDepartment of Biomedical Science, College of Health Sciences, QU Health, Qatar University, Doha 2713, Qatar.
Hind Hassan HabishDepartment of Cancer Genetics, Medical Oncology, National Center of Cancer Care and Research, Hamad Medical Corporation, Doha 3050, Qatar.
Reem Al-SulaimanDepartment of Adult and Pediatric Medical Genetics, Hamad Medical Corporation, Doha 3050, Qatar.
Salha Bujassoum Al-BaderDepartment of Cancer Genetics, Medical Oncology, National Center of Cancer Care and Research, Hamad Medical Corporation, Doha 3050, Qatar.
Hamad Medical Corporation · QANational Center for Cancer Care and Research · QAQatar University · QA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lynch syndrome (LS) is the most common cause of hereditary colorectal cancers (CRC) and is associated with an increased risk for ovarian and endometrial cancers. There is lack of knowledge on the epidemiology of LS in the non-Caucasian populations especially in Qatar. The aim of this retrospective study is to explore the prevalence of LS in a selected high-risk cohort in the State of Qatar in addition to investigating the frequency and genotype-phenotype correlation associated with mismatch repair genes pathogenic variants. Retrospective review of medical records of 31 individuals with LS, 20 affected with colorectal cancer and 11 unaffected with family history of cancers, referred from January 2017 until August 2020. The prevalence of LS among affected and unaffected patients is 22% (20/92) and 2.2% respectively. Among affected individuals,

Indexed as

Colorectal Neoplasms, Hereditary NonpolyposisGenetic Association StudiesHumansPrevalenceQatarRetrospective Studiescolorectal cancerLynch syndromemismatch repair genespathogenic variantsQatar

Identifiers

PMID36421850
PMCPMC9690077
OpenAlexW4309683208

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.