ReviewAntioxidants (Basel, Switzerland)2022
ANTIAGE-DB: A Database and Server for the Prediction of Anti-Aging Compounds Targeting Elastase, Hyaluronidase, and Tyrosinase.
Review in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Article
- Dissecting shared genetic architecture between pan-cancer and aging-related traits: a genome-wide cross-trait analysis.Biogerontology · 2026Article
- Polymer-Based Microencapsulation ofPharmaceutics · 2026Article
- Inhibitory Effects of Grape Stem Extracts From Douro Varieties on Skin-Aging Enzymes: A Sustainable Source of Cosmeceutical Agents.Journal of cosmetic dermatology · 2026Article
- Investigating the Ligand-Binding Properties of N-arylbenzimidazoles as Novel Elastase Inhibitors.ChemMedChem · 2026Article
- Review
- Bioactive Potential ofPlants (Basel, Switzerland) · 2025Article
- Skin Aging: Insights into the Role of Fatty Acids.Current pharmaceutical design · 2025Review
- Research on the mechanisms of plant bioactive metabolites in anti-skin aging and future development prospects.Frontiers in pharmacology · 2025Review
- Computational Approach to Identifying New Chemical Entities as Elastase Inhibitors with Potential Antiaging Effects.International journal of molecular sciences · 2024Article
- Anti-Skin Aging and Cytotoxic Effects of Methanol-ExtractedPlants (Basel, Switzerland) · 2024Article
- Anti-Skin Aging Potential, Antibacterial Activity, Inhibition of Single-Stranded DNA-Binding Protein, and Cytotoxic Effects of Acetone-ExtractedPlants (Basel, Switzerland) · 2024Article
- Cytotoxicity and Multi-Enzyme Inhibition ofPlants (Basel, Switzerland) · 2024Article
- Research Progress of Bioactive Components inMolecules (Basel, Switzerland) · 2024Review
- Lutein derived from Xenostegia tridentata exhibits anticancer activities against A549 lung cancer cells via hyaluronidase inhibition.PloS one · 2024Article
- A critical assessment of bioactive compounds databases.Future medicinal chemistry · 2024Review
- TheFrontiers in pharmacology · 2023Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Natural products bear a multivariate biochemical profile with antioxidant, anti-inflammatory, antibacterial, and antitumoral properties. Along with their natural sources, they have been widely used both as anti-aging and anti-melanogenic agents due to their effective contribution in the elimination of reactive oxygen species (ROS) caused by oxidative stress. Their anti-aging activity is mainly related to their capacity of inhibiting enzymes like Human Neutrophil Elastase (HNE), Hyaluronidase (Hyal) and Tyrosinase (Tyr). Herein, we accumulated literature information (covering the period 1965-2020) on the inhibitory activity of natural products and their natural sources towards these enzymes. To navigate this information, we developed a database and server termed ANTIAGE-DB that allows the prediction of the anti-aging potential of target compounds. The server operates in two axes. First a comparison of compounds by shape similarity can be performed against our curated database of natural products whose inhibitory potential has been established in the literature. In addition, inverse virtual screening can be performed for a chosen molecule against the three targeted enzymes. The server is open access, and a detailed report with the prediction results is emailed to the user. ANTIAGE-DB could enable researchers to explore the chemical space of natural based products, but is not limited to, as anti-aging compounds and can predict their anti-aging potential. ANTIAGE-DB is accessed online.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.