Evidence map›Paper›PMID 36421255›Full record

ArticleAntibiotics (Basel, Switzerland)2022

Deep Transfer Learning Enables Robust Prediction of Antimicrobial Resistance for Novel Antibiotics.

Yunxiao Ren, Trinad Chakraborty, Swapnil Doijad, Linda Falgenhauer, Jane Falgenhauer, Alexander Goesmann, Oliver Schwengers, Dominik Heider

Abstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yunxiao RenDepartment of Data Science in Biomedicine, Faculty of Mathematics and Computer Science, Philipps-University of Marburg, 35032 Marburg, Germany.ORCID 0000-0002-0076-0857
Trinad ChakrabortyInstitute of Medical Microbiology, Justus Liebig University Giessen, 35392 Giessen, Germany.
Swapnil DoijadInstitute of Medical Microbiology, Justus Liebig University Giessen, 35392 Giessen, Germany.ORCID 0000-0002-0932-8542
Linda FalgenhauerGerman Center for Infection Research, Partner Site Giessen-Marburg-Langen, 35392 Giessen, Germany.
Jane FalgenhauerInstitute of Medical Microbiology, Justus Liebig University Giessen, 35392 Giessen, Germany.
Alexander GoesmannGerman Center for Infection Research, Partner Site Giessen-Marburg-Langen, 35392 Giessen, Germany.
Oliver SchwengersGerman Center for Infection Research, Partner Site Giessen-Marburg-Langen, 35392 Giessen, Germany.
Dominik HeiderDepartment of Data Science in Biomedicine, Faculty of Mathematics and Computer Science, Philipps-University of Marburg, 35032 Marburg, Germany.ORCID 0000-0002-3108-8311

Funding

Federal Ministry of Education and Research 031L0209B
6 · The paper itself

Abstract

Antimicrobial resistance (AMR) has become one of the serious global health problems, threatening the effective treatment of a growing number of infections. Machine learning and deep learning show great potential in rapid and accurate AMR predictions. However, a large number of samples for the training of these models is essential. In particular, for novel antibiotics, limited training samples and data imbalance hinder the models' generalization performance and overall accuracy. We propose a deep transfer learning model that can improve model performance for AMR prediction on small, imbalanced datasets. As our approach relies on transfer learning and secondary mutations, it is also applicable to novel antibiotics and emerging resistances in the future and enables quick diagnostics and personalized treatments.

Indexed as

antimicrobial resistancesmall data with imbalanced labeltransfer learning

Identifiers

PMID36421255
PMCPMC9686617

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.